San Diego Padres vs. Chicago Cubs Outlook, 6/29/2026 MLB Picks, Top Bets & Odds

Home » San Diego Padres vs. Chicago Cubs Outlook, 6/29/2026 MLB Picks, Top Bets & Odds

  • Matchup: San Diego Padres vs Chicago Cubs
  • Date: Monday, June 29, 2026
  • Venue: Wrigley Field, Chicago, IL
  • Broadcast: Marquee Network
  • Betting Lines: San Diego (+106) Chicago (-128)

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The San Diego Padres (43-38) head to Wrigley Field on Monday to challenge the Chicago Cubs (45-38). The betting odds for this matchup place San Diego at +106 while Chicago opens at -128, with the total set at 8 runs. The expected starting pitchers for this game are German Marquez and Shota Imanaga.

MLB Predictions for San Diego Padres

This season, the Padres have a slugging percentage of .366, having struck out 680 times and drawn 271 walks. They have achieved 311 RBIs and 583 hits, reflected in a batting average of .221. The team has recorded 117 doubles and launched 83 home runs, accumulating a total of 319 runs scored and an on-base percentage of .297. As a whole, the San Diego Padres are scoring an average of 3.9 runs per game, placing them 29th in Major League Baseball.

With a strikeout-to-walk ratio of 2.36, the Padres pitching staff maintains a team WHIP of 1.30. They have allowed 80 home runs and a total of 330 runs, ranking 6th in MLB. The Padres have given up 655 hits (averaging 8.2 per 9 innings) and 312 earned runs, leading to a team ERA of 3.91 (10th in MLB). Collectively, the pitching staff has struck out 669 batters, while issuing 283 walks, resulting in a FIP of 4.02 for the season.

This season, Padres relievers have entered games with runners on base 82 times and have appeared in high-leverage situations 94 times. Their bullpen boasts 52 holds (ranking 7th in MLB) and a save percentage of 73.5%, successfully converting 25 out of 34 save opportunities while blowing 9 chances. They have inherited 140 runners this season, with 31.4% of them scoring. So far, the Padres have utilized 277 different relievers in 2026.

Defensively, the Padres have turned 70.1% of batted balls into outs across 6,471 innings, ranking them 14th in professional baseball. They have tallied 2,157 putouts, 725 assists, and committed 27 errors this year, tying for 2nd in MLB with a .991 fielding percentage, while successfully executing 71 double plays.

Marquez holds a career record of 71-74 with a FIP of 4.63, having faced 5,035 batters in his career. He has surrendered 1,206 hits (9.2 hits per nine innings) alongside 366 walks, resulting in an ERA of 4.70 (614 earned runs allowed) and a WHIP of 1.338. Over 1,175 innings pitched, Marquez has accumulated 1,088 strikeouts.

The Chicago Cubs feature an on-base percentage of .336 and a batting average of .242 this season. They have struck out 701 times (13th in MLB) and gathered a total of 685 hits. The Cubs have so far recorded 99 home runs and 381 RBIs, boasting a team slugging percentage of .404 and scoring an average of 4.93 runs per game (6th in MLB). They have compiled 133 doubles this season, earning 367 walks for a total of 409 runs.

The Cubs’ pitching staff has allowed 370 runs this season, resulting in a team ERA of 4.27 (350 of which are earned runs). They have given up 126 home runs and concede 4.52 runs per 9 innings (14th in MLB). The team’s WHIP stands at 1.245, with a staff FIP of 4.72 for the season. Their strikeout-to-walk ratio is 7.90, with 650 strikeouts versus 257 walks, ranking them 14th in hits allowed (661 total).

Chicago’s relievers have inherited 115 base runners, with a 30.4% scoring rate. Their bullpen has taken the mound in high-leverage situations 78 times and with base runners 81 times. In 58 save situations, they have achieved 28 holds and suffered 14 blown saves, placing them 28th in save rate at 46.2%. A total of 268 relief pitchers have appeared for the Cubs this season.

Defensively, the Cubs have a 72.6% defensive efficiency over 6,636 innings, which ranks 2nd in professional baseball. The Cubs have turned 57 double plays and maintain a respectable .989 fielding percentage (5th in MLB). This season, they have recorded 764 assists, committed 33 errors, and achieved 2,212 putouts.

Imanaga has a career record of 29-17, with a 3.53 ERA and allowing 7.5 hits per 9 innings pitched. His strikeout-to-walk ratio is an impressive 4.92, facing 1,630 opposing hitters throughout his career. He has yielded 161 earned runs, maintaining a WHIP of 1.017 and a FIP of 3.5. In total, he has allowed 340 hits while amassing 379 strikeouts across 410 innings pitched.

Who will come out on top in tonight’s MLB contest against the spread or moneyline?

Pick: Endorse Chicago (-128)

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Pick: Chicago Cubs (-128)
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