St. Louis Cardinals vs. Los Angeles Angels Analysis, 7/22/2026 MLB Insights, Top Picks & Odds

Home » St. Louis Cardinals vs. Los Angeles Angels Analysis, 7/22/2026 MLB Insights, Top Picks & Odds

  • Matchup: St. Louis Cardinals vs Los Angeles Angels
  • Date: Wednesday, July 22, 2026
  • Venue: Angel Stadium, Anaheim, CA
  • Broadcast: FanDuel Sports Network West
  • Betting Lines: St. Louis (-144), Los Angeles (+120)

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The St. Louis Cardinals (51-48) are set to visit Angel Stadium this Wednesday to face off against the Los Angeles Angels (40-61). The betting odds indicate the Cardinals as favorites at -144, while the Angels are positioned at +120. The game total is projected at 9 runs. Scheduled to pitch are Michael McGreevy for the Cardinals and Reid Detmers for the Angels.

MLB Predictions for Jo Adell and the Los Angeles Angels

The Cardinals boast a slugging percentage of .387 while they have struck out 765 times and drawn 321 walks this season. Accumulating 434 RBIs and 801 hits, their batting average stands at .242. The team has hit 133 doubles and launched 109 home runs, contributing to 446 runs scored. As a unit, the St. Louis Cardinals average 4.5 runs per game, ranking 13th in the league.

With a team ERA of 4.15, the Cardinals rank 12th in the majors, having recorded 745 strikeouts. Their pitching staff has allowed 99 home runs and a total of 443 runs (13th in MLB). They have also walked 332 batters, with a team FIP of 4.17 recorded this season. St. Louis pitchers have surrendered 841 hits (averaging 8.6 per 9 innings) and 407 earned runs, yielding a strikeout-to-walk ratio of 2.24 and a WHIP of 1.33.

This season, Cardinals relievers have taken the mound with runners on base 109 times and experienced 118 high leverage situations. The bullpen has successfully recorded 67 holds (4th in MLB) and achieved a save rate of 62.5%, converting 30 out of 48 save opportunities. Out of 161 inherited runners, 35.4% have scored. For the year, a total of 337 relievers have been called upon.

Thus far, the Cardinals have compiled 2,650 putouts, 930 assists, and committed 46 errors, leading to a fielding percentage of .987—placing them 9th in the majors. They have executed 88 double plays and converted 69.8% of balls in play into outs across 7,950 innings, ranking 17th overall.

Michael McGreevy, with a career record of 15-11, holds a FIP of 3.41 after facing 913 hitters in his major league tenure. He has allowed 211 hits (8.4 hits per nine innings) and issued 46 walks. His ERA currently stands at 3.46 with 87 earned runs allowed, and his WHIP is 1.136. Over 226 innings pitched, McGreevy has notched 147 strikeouts in his professional career.

The Los Angeles Angels have generated a team slugging percentage of .388 and score an average of 4.33 runs per game, ranking 19th in the league. They have tallied 154 doubles, drawn 324 walks, and scored 437 runs. With 111 home runs this season, the Angels have also recorded 421 RBIs. However, they have struck out 958 times (1st in MLB) and logged 812 hits, resulting in a team on-base percentage of .315 and a batting average of .239.

As a pitching staff, the Angels have a WHIP of 1.377 and a FIP of 4.33. They maintain a strikeout-to-walk ratio of 9.00, with 887 strikeouts compared to 429 walks. They have conceded 795 hits, placing them 10th in MLB, while allowing 109 home runs and yielding an average of 5.04 runs per 9 innings (24th in the league). Overall, the Angels’ pitchers have surrendered 498 runs this season, posting a team ERA of 4.60 from 454 earned runs.

The Angels’ relief core has been involved in 83 save situations, earning 51 holds alongside 18 blown saves. They have participated in 30 save opportunities, successfully converting 12 of those. Los Angeles’ relievers have inherited a score rate of 36.6% of 175 inherited runners. Their bullpen has pitched 108 times in high leverage conditions, ranking 30th in the league with a save rate of 40.0%, utilizing a total of 320 relievers this year.

Across 8,001 innings, the Angels have recorded a defensive efficiency rating of 69.9% (15th in MLB). With 63 double plays and a fielding percentage of .983 (21st in MLB), they have amassed 846 assists, committed 59 errors, and achieved 2,667 putouts throughout the season.

This season, Reid Detmers has allowed 526 hits and accumulated 628 strikeouts over 563 innings pitched. Holding a career record of 24-37, Detmers’ ERA stands at 4.65 and he has surrendered 8.4 hits per 9 innings. He has permitted 291 earned runs, with a WHIP of 1.315 and a FIP of 4.6. His strikeout-to-walk ratio is 2.92, having faced 2,415 hitters in his career.

Who will triumph in tonight’s MLB match, either by spread or moneyline?

Prediction: Back St. Louis (-144)

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Pick: St. Louis Cardinals (-144)
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