Chicago Cubs vs. St. Louis Cardinals Outlook: 7/29/2026 MLB Picks, Top Bets & Odds

Home » Chicago Cubs vs. St. Louis Cardinals Outlook: 7/29/2026 MLB Picks, Top Bets & Odds

  • Matchup: Chicago Cubs vs. St. Louis Cardinals
  • Date: Wednesday, July 29, 2026
  • Venue: Busch Stadium, St. Louis, MO
  • Broadcast: Cardinals.TV
  • Betting Odds: Chicago (-128) St. Louis (+106)

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This Wednesday, the St. Louis Cardinals (53-53) will host the Chicago Cubs (60-46) at Busch Stadium. The moneyline for this matchup features the Cubs at -128 and the Cardinals at +106, with the over/under set at 8.5. Scheduled starters are Matthew Boyd and Dustin May.

MLB Predictions and Betting Odds for Chicago Cubs

The Chicago Cubs are currently averaging 5.2 runs per game, ranking 3rd in Major League Baseball. With a total of 548 runs scored, they maintain an on-base percentage of .339. This season, the Cubs have achieved 173 doubles and hit 133 home runs, accumulating 514 RBIs and 901 hits, while posting a batting average of .248. Their slugging percentage stands at .415, with 913 strikeouts and 460 walks recorded.

The Cubs’ pitching staff has a collective WHIP of 1.27 and a strikeout-to-walk ratio of 2.57. They have allowed 161 home runs and 468 total runs this season, placing them 12th in the league. The team’s ERA is 4.22 (17th overall), with 825 strikeouts. Cubs pitchers have walked 321 batters, and their FIP this year is at 4.73.

Throughout the season, Chicago pitchers have faced players on base 107 times and have appeared in high-leverage situations 103 times. The bullpen has recorded 38 holds but ranks 29th in the league for this statistic. With a 56.4% save percentage, the bullpen has been involved in 83 save situations, successfully securing 22 saves while failing 17 times. They have inherited 154 base runners, with 31.8% scoring. So far, the Cubs have utilized 347 relief pitchers this year.

With 2,833 putouts, 982 assists, and 41 errors, the Cubs boast a .989 fielding percentage, placing them 2nd in the league. They have executed a total of 80 double plays and have turned 71.8% of balls put into play into outs over 8,499 innings, ranking them 3rd in professional baseball.

Matthew Boyd, holding a career record of 66-78, has faced 4,860 hitters, surrendering 1,109 hits (8.7 hits per nine innings) alongside 353 walks. His career ERA is 4.54, allowing 578 earned runs, with a WHIP of 1.275. Over 1,147 innings pitched, Boyd has accumulated 1,100 strikeouts.

The St. Louis Cardinals possess an on-base percentage of .315, with a team batting average of .240 this season. They have struck out 817 times (27th in MLB) and have produced 849 hits. St. Louis has hit 112 home runs, with a total of 457 runs batted in. The team’s slugging percentage is .381, averaging 4.42 runs per game (16th across the league). They have recorded 143 doubles while drawing 340 walks.

On the pitching side, the Cardinals have allowed 474 runs (with an ERA of 4.16) and have yielded 106 home runs. They permit 4.51 runs per nine innings, ranking 14th overall. Their staff WHIP is 1.339 with a FIP of 4.14 this season. The strikeout-to-walk ratio sits at 7.80 (815 strikeouts against 355 walks). St. Louis ranks 22nd in MLB for total hits given up, with 912.

With 122 save situations, the Cardinals have achieved 69 holds but also experienced 19 blown saves. St. Louis has used their bullpen in 50 save opportunities, achieving 31 saves. Their relievers have inherited 35.9% of 167 runners on base. They have participated in 127 high-leverage situations and 114 situations with runners on base, rank 16th in MLB regarding save percentage at 62.0%, having utilized 355 relief pitchers this year.

Over 8,517 innings played, the Cardinals have a defensive efficiency of 69.4% (20th in the majors). Their fielding percentage is at .988 (7th overall), with 96 double plays turned, 987 assists, and 47 errors so far this season.

Dustin May has conceded 380 hits during his professional career, along with 400 strikeouts in 428 innings pitched. Holding a record of 24-27, May has a 4.04 ERA, allowing 8.0 hits per nine innings and 192 earned runs. His WHIP stands at 1.229, with a FIP of 4.0. He has faced 1,797 batters, with a K/BB ratio of 2.74.

Who will emerge victorious in tonight’s MLB showdown, betting against the spread or moneyline?

Prediction: Bet on St. Louis (+106)

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Pick: St. Louis Cardinals (+106)
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