USC Trojans and Purdue Boilermakers Prediction for 9/13/2025 College Football Picks, Best Bets & Odds

Home » USC Trojans and Purdue Boilermakers Prediction for 9/13/2025 College Football Picks, Best Bets & Odds

Matchup: USC Trojans vs Purdue Boilermakers

Date: Saturday, September 13, 2025

Venue: Ross-Ade Stadium, West Lafayette, IN

Broadcast: CBS Paramount+

Point Spread: Boilermakers (+21.0)

Total Points Over-Under: 58.5

The Purdue Boilermakers (2-0) are set to take on the USC Trojans (2-0) at Ross-Ade Stadium on Saturday, September 13, 2025. Purdue enters the matchup as 21.0-point underdogs, with the over/under line set at 58.5.

Boasting a 2-0 record, the USC Trojans come into this game after a convincing 59-20 victory over the Georgia Southern Eagles. In that contest, the Trojans executed 33 rushing attempts for a total of 309 yards, averaging an impressive 9.4 yards per carry. Overall, USC ran 63 plays, accumulating 755 total yards. On the defensive side, they allowed 24 completions from 45 attempts, yielding 235 passing yards with a completion rate of 53.3%. When it came to rushing defense, the Trojans conceded 142 yards on 33 carries, averaging 4.3 yards per rush.

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Offensively, the USC Trojans are scoring an average of 66.0 points per game (PPG). The team’s ground attack averages 271.0 yards per game, positioning them 10th in the nation. Across the season, USC has amassed a total of 1,352 yards, with 7 touchdown passes and 10 rushing touchdowns. They have achieved 55 first downs but have incurred 13 penalties for 138 yards and committed 2 turnovers.

In terms of passing yards allowed, the Trojans rank 68th in Division 1, having yielded 394 passing yards, which is an average of 197.0 yards per game at a completion percentage of 60.3%. Overall, their defense gives up an average of 300.5 yards per game, ranking 54th nationally, and they have allowed 4 passing touchdowns. Opponents are averaging 3.3 rushing yards per carry, totaling 103.5 rushing yards per game. Over the first two games of the season, the Trojans have given up a total of 207 yards on the ground, ranking 58th in team defense with 16.5 points allowed per game.

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The Boilermakers enter this matchup with a 2-0 record as well. In their last outing, they secured a 34-17 win against the Southern Illinois Salukis. Purdue managed to average 4.0 yards per carry, racking up 214 rushing yards on 53 attempts. They ended the game with a total of 384 yards and ran 76 plays at an average of 5.1 yards per play. On defense, the Boilermakers allowed a completion rate of 58.8%, giving up 202 yards on 20 out of 34 passing attempts. They restricted opponents to just 81 rushing yards over 26 attempts, averaging 3.1 yards per carry.

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From a scoring perspective, the Boilermakers are averaging 32.5 points per game, placing them 52nd in Division 1. Purdue’s offense has produced 408.5 yards per game, ranking them 65th nationally. They have accumulated 55 penalty yards from 5 infractions, placing them 131st in Division 1. Thus far this season, they have recorded 52 first downs. The Boilermakers have also accounted for 510 passing yards, with an average of 255.0 yards per game, ranking 46th in D-1. On the ground, they average 153.5 rushing yards per game, totaling 307 yards for the season.

Purdue has allowed 197 rushing yards this season (98.5 yards per game) and 1 rushing touchdown. Through the air, they have conceded 144.5 yards per game and 1 touchdown, placing them 29th in Division 1. Currently, they have not yet forced a turnover. The Boilermakers’ defense has participated in 112 plays, ranking 23rd in the nation, and they are giving up only 8.5 PPG, securing the 16th spot in Division 1.

Who will prevail in tonight’s matchup between the Trojans and Boilermakers against the spread?

Josh’s Prediction: Pick the Boilermakers +21.0

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