Chicago Cubs vs. Arizona Diamondbacks Insights, 8/25/2026 MLB Predictions, Top Picks & Odds

Home » Chicago Cubs vs. Arizona Diamondbacks Insights, 8/25/2026 MLB Predictions, Top Picks & Odds

  • Matchup: Chicago Cubs vs Arizona Diamondbacks
  • Date: Tuesday, August 25, 2026
  • Venue: Chase Field, Phoenix, AZ
  • Broadcast: DBACKS.TV
  • Betting Odds: Chicago (-152) Arizona (+126)

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The Arizona Diamondbacks (69-62) are set to face off against the Chicago Cubs (75-56) at Chase Field this Tuesday. The moneyline for this game lists Chicago at -152, while Arizona opens at +126. The over/under for the contest is established at 9 runs. The anticipated starting pitchers are Clay Holmes and Brandon Pfaadt.

MLB Insights Corbin Carroll Arizona Diamondbacks predictions betting odds

The Chicago Cubs boast a slugging percentage of .423 and have recorded 1,129 strikeouts, while drawing walks 558 times. They have accumulated 645 RBIs and logged 1,125 hits this season, maintaining a team batting average of .250. This season, the Cubs have registered 219 doubles and 174 home runs, driving in 684 runs with an on-base percentage (OBP) of .339. As a unit, the Cubs are averaging 5.2 runs per game, ranking 1st in Major League Baseball.

The Cubs have a strikeout-to-walk ratio of 2.56, and their pitching staff has recorded a cumulative WHIP of 1.26. Cubs pitchers have allowed 196 home runs and 569 runs (ranking 12th in the league). Chicago has seen 1,080 hits allowed (8.3 per 9 innings) and 537 earned runs, compiling a team ERA of 4.12 (15th in the league) while totaling 1,007 strikeouts. They’ve walked 393 batters, and their FIP currently stands at 4.68.

This season, the Cubs have utilized 423 relief pitchers. The relievers have inherited 180 base runners, with 30.6% of those scoring. The bullpen has recorded 49 holds (30th in the league) and has entered 131 games with runners on base as well as 128 high-leverage situations. Chicago’s bullpen has accumulated 29 saves, having failed to convert 21 of 50 save chances, resulting in a 58.0% save percentage across 105 save opportunities.

The Cubs have achieved a 72.0% rate of converting balls in play into outs throughout their 10,548 defensive innings, placing them second overall in professional baseball. The Chicago Cubs have logged 3,516 putouts, 1,234 assists, and committed 49 errors this season. Their fielding percentage stands at an impressive .990, ranking 1st in the league, along with 100 double plays executed.

Holmes has pitched a total of 519 innings, amassing 494 strikeouts throughout his professional career, which features a career 3.62 ERA (209 earned runs) and a WHIP of 1.297. He has allowed 449 hits (7.8 hits per nine innings) and issued 224 walks, while maintaining a FIP of 3.57 against 2,231 batters faced in the majors, sporting a career record of 37-32.

The Diamondbacks, meanwhile, hold a team slugging percentage of .401 and average 4.56 runs per game (11th in MLB). They have notched 228 doubles, drawn 443 walks, and scored 598 runs. Arizona has also hit 129 home runs this season, driving in 570 RBIs. They have been struck out 951 times (29th in baseball) and recorded 1,077 hits, finishing with a team OBP of .318 and a batting average of .245.

As a unit, the Diamondbacks hold a WHIP of 1.294 with a FIP of 4.39 on the season. They rank 22nd in the league for total hits allowed, with a cumulative of 1,119. The Arizona pitching staff has conceded 589 runs, achieving a team ERA of 4.19 (541 earned runs). Their strikeout-to-walk ratio stands at 6.90 (892 strikeouts versus 386 walks), having allowed 153 home runs and averaging 4.56 runs per 9 innings (19th in MLB).

Currently, they rank 11th in the league with a save success rate of 68.1%, having deployed 433 relievers this season. The bullpen pitchers have been called into 138 high-leverage situations and appeared 115 times with runners on base. With 121 save chances, the Diamondbacks have earned 73 holds and recorded 15 blown saves. Arizona relievers have entered 47 save opportunities, securing 32 saves while inheriting a score rate of 25.3% from 170 inherited runners.

Over the course of 10,467 innings, the Diamondbacks have a defensive efficiency of 71.1% (7th in baseball). The Arizona Diamondbacks have executed 116 double plays and own a fielding percentage of .990 (2nd in professional baseball), recording 1,142 assists, 49 errors, and 3,489 putouts this season.

Pfaadt, in his professional career, has allowed 578 hits and has achieved 495 strikeouts across 552 innings. He has given up 296 earned runs while maintaining a WHIP of 1.280 and a FIP of 4.8. With a strikeout-to-walk ratio of 3.84, he has faced 2,351 hitters in his MLB career, securing a record of 34-29 and an earned run average of 4.82, permitting 9.4 hits per 9 innings.

Who will emerge victorious in tonight’s MLB matchup against the spread or moneyline?

Prediction: Back Chicago (-152)

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Pick: Chicago Cubs (-152)
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