Colorado Buffaloes vs Houston Cougars Prediction for College Football Picks, Best Bets & Odds on 9/12/2025

Home » Colorado Buffaloes vs Houston Cougars Prediction for College Football Picks, Best Bets & Odds on 9/12/2025
  • Matchup: Colorado Buffaloes vs Houston Cougars
  • Date: Friday, September 12, 2025
  • Venue: TDECU Stadium, Houston, TX
  • Broadcasting: ESPN/ESPN+
  • Betting Line: Cougars favored by 4.5 points
  • Total Points: 44.5

TDECU Stadium will host the Colorado Buffaloes (1-1) as they face the unbeaten Houston Cougars (2-0) on Friday, September 12, 2025. The Buffaloes enter the match as 4.5-point underdogs, with a total points line set at 44.5.

The Colorado Buffaloes have a record of 1-1 this season. Their most recent game was a solid performance against the Delaware Fightin’ Blue Hens, where they secured a convincing victory, finishing 31-7. Throughout the game, Colorado executed 70 plays accumulating 398 yards. They achieved 131 rushing yards on 39 attempts, averaging 3.4 yards per carry. Defensively, the Buffaloes allowed 84 rushing yards on 30 carries, averaging 2.8 yards per run. In the passing game, the Buffaloes conceded 312 yards, allowing 18 completions out of 36 attempts—resulting in a completion rate of 50.0%.

College Football Predictions by Stephon Johnson - Houston Cougars

This season, the Buffaloes have accumulated a total of 703 yards. They have found the end zone 3 times through the air and 3 times on the ground without any turnovers to date. Colorado’s offense has recorded 40 first downs while being penalized 9 times for a total of 85 yards. In terms of rushing, they are averaging 138.5 yards per game, placing them 89th nationally, while their scoring average stands at 25.5 points per game.

Defensively, Colorado ranks 59th in the nation, allowing an average of 17.0 points per game. Opponents are averaging 5.2 yards per carry and a total of 202.0 rushing yards against them this season. Overall, they have conceded 404 rushing yards over 2 games. As for passing defense, the Buffaloes have allowed 455 yards, placing them 90th in Division 1, with an average of 227.5 passing yards surrendered per outing, along with a completion percentage of 54.4%. In total yards allowed, Colorado sits at 116th in Division 1, with 429.5 yards per game, yielding 1 touchdown through the air and 3 on the ground.

The Houston Cougars, coming off a strong start to their season at 2-0, last played against the Rice Owls, winning decisively with a score of 35-9. In that matchup, the Cougars averaged 5.4 yards per carry with a total of 204 yards on 38 rushing attempts. Houston completed the game with 392 total yards over 60 plays at a rate of 6.5 yards per play. Their secondary faced some challenges, permitting a completion rate of 84.6%, allowing 51 yards from 11 completions out of 13 attempted through the air. The ground defense held firm, allowing 177 yards on 53 carries (3.3 yards per carry).

When it comes to scoring, the Cougars are currently averaging 31.0 points per game, ranking 56th nationally. They hold an average of 367.5 total yards per game, placing them 81st in Division 1. The Cougars have also incurred 88 yards in penalties across 10 infractions, ranking 88th in the nation. Their performance has accounted for 32 first downs. So far this season, Houston has thrown for a combined 340 yards with an average of 170.0 passing yards per game, positioning them 104th nationally, while they have averaged 197.5 rushing yards per game totaling 395 rushing yards overall.

The Cougars excel on defense, allowing just 4.5 points per game, which ranks them 5th in Division 1. On the ground, they have relinquished 216 yards total (108.0 yards per game) and a single rushing touchdown this season. In the passing game, they have yet to allow any touchdowns, averaging just 78.0 passing yards against them per game, ranking 3rd nationally. The Cougars’ defense has been active in 124 plays, which ranks 48th in the country, and they have secured 1 fumble recovery along with 3 interceptions this season.

Who will prevail in this clash between the Buffaloes and Cougars?

Expert Prediction: Bet on the Cougars -4.5

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Pick: Houston Cougars -4.5
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