Illinois Fighting Illini vs Indiana Hoosiers Prediction for College Football Picks, Best Bets & Odds on 9/20/2025

Home » Illinois Fighting Illini vs Indiana Hoosiers Prediction for College Football Picks, Best Bets & Odds on 9/20/2025

Matchup: Illinois Fighting Illini vs Indiana Hoosiers

Date: Saturday, September 20, 2025

Venue: Memorial Stadium, Bloomington, IN

Broadcast: NBC

Betting Odds: Hoosiers favored by 4.0 points

Over/Under Total: 52.5

The Illinois Fighting Illini, currently boasting a 3-0 record, will travel to Memorial Stadium on September 20, 2025, to challenge the Indiana Hoosiers, who also hold a 3-0 record. Illinois is listed as a 4.0-point underdog by the oddsmakers. The projected total for the game is set at 52.5 points.

The Illinois Fighting Illini are entering this contest with a perfect mark of 3-0 this season. In their prior game, they achieved a commanding 38-0 victory over the Western Michigan Broncos. During that matchup, they executed 63 plays, accumulating 358 total yards. The Fighting Illini excelled on the ground, rushing the ball 37 times for 162 yards, averaging 4.4 yards per carry. Defensively, they permitted 113 rushing yards on 34 attempts, an average of 3.3 yards per carry. Through the air, Illinois allowed 13 throws to be completed out of 24, for a total of 91 yards, resulting in a completion rate of 54.2%.

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Regarding scoring, the Illinois Fighting Illini are ranked at an impressive 45.0 points per game. They average 164.7 rushing yards, placing them 70th in the nation for rushing efficiency. This season, the Fighting Illini have racked up a total of 1,217 offensive yards. When it comes to touchdowns, they have tallied 8 through the air and 9 on the ground. With 66 first downs so far, they have been penalized 17 times for 157 yards but have not committed a turnover yet.

In terms of defensive performance, the Fighting Illini are among the top teams in college football, ranking 5th by allowing only 7.3 points per game. They restrict opponents to an average of 2.6 yards per carry and 74.0 rushing yards per game, having conceded a mere total of 222 rushing yards over three games. In passing defense, they have allowed 581 yards, ranking 63rd nationally, which averages out to 193.7 passing yards per game with a completion percentage against of 56.4%. Overall, they’ve allowed 267.7 total yards per game, placing them at 29th in the country, with only 2 passing touchdowns and no touchdowns on the ground conceded this season.

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The Hoosiers also enter this game with a flawless 3-0 record. In their latest outing, they triumphed over the Indiana State Sycamores with an overwhelming score of 73-0. Indiana showcased a robust running game, achieving 8.1 yards per carry with a total of 301 rushing yards on 37 attempts. They concluded that game with 680 total yards, averaging 10.1 yards per play across 67 offensive plays. On defense, Indiana allowed a completion rate of 55.0%, giving up 38 yards through the air on 11 completions out of 20 attempts, while limiting rushed attempts to 39 yards on 31 carries (1.3 yards per rush).

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When it comes to scoring, the Hoosiers are ranked 7th in college football, averaging 52.0 points per game. Indiana stands at 3rd in total offense with an average of 591.7 yards per game. However, they have faced 110 yards in penalties over 13 infractions, ranking 106th in D-1 for penalty impact. They’ve earned 91 first downs this season, with a passing yard total of 852 and an average of 284.0 passing yards per game, landing them at 28th in Division 1. The rushing game has been particularly impressive, averaging 307.7 yards per game and a total of 923 rushing yards so far.

Defensively, Indiana has permitted a total of 346 rushing yards (an average of 115.3 yards per game) along with 2 rushing touchdowns this season. They have yet to allow any passing touchdowns and have given up 105.3 yards through the air per contest, which ranks 6th in D-1. This season, they have allowed just 23 points, with 1 fumble and 4 interceptions recorded. With 149 plays faced, the Hoosiers’ defense ranks 20th nationally, allowing 7.7 points per game, placing them 6th overall in the country.

Which team will secure victory in this thrilling Fighting Illini/Hoosiers clash?

Prediction: Bet on the Hoosiers -4.0

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