Arizona Cardinals vs. Los Angeles Rams Outlook, 10/18/2026 NFL Selections, Top Wagers & Odds Week 6

Home » Arizona Cardinals vs. Los Angeles Rams Outlook, 10/18/2026 NFL Selections, Top Wagers & Odds Week 6

  • Matchup: Arizona Cardinals vs Los Angeles Rams
  • Date: Sunday, October 18, 2026
  • Venue: SoFi Stadium, Inglewood, CA
  • Broadcast: FOX
  • Betting Odds: Rams -13.5
  • Total Points: 52

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The Arizona Cardinals (1-4) will visit SoFi Stadium this Sunday to face off against the Los Angeles Rams (2-3). According to Las Vegas odds, the Rams are favored by 13.5 points with an over/under set at 52.

The Cardinals enter the game with a 1-4 record for the season. In their previous outing, they suffered a defeat against the Detroit Lions, ending the game 45-21. Jeremiyah Love led the Cardinals’ rushing attack with 12 carries for just 22 yards (1.8 yards per attempt). Kendrick Bourne averaged 14.0 yards per catch, accumulating 70 yards on 5 receptions. Quarterback Jacoby Brissett completed 29 of 47 passes for 292 yards and 3 touchdowns, achieving a QB rating of 91.8 despite throwing 1 interception. On defense, the Cardinals allowed 163 rushing yards on 32 attempts, averaging 5.1 yards per rush. Through the air, they conceded 249 yards on 19 completions out of 30 attempts, maintaining a completion rate of 63.3%. Overall, they executed 66 plays, totaling 327 yards, and managed 56 rushing yards from 18 attempts, averaging 3.1 yards per carry.

NFL Picks Trey McBride Arizona Cardinals Predictions Best Bet Odds

Looking at scoring potential, the Cardinals average 21.6 points per game. Their rushing game averages 91.6 yards per outing, ranking 23rd in the league. This season, the Cardinals have generated 1,506 total yards, achieved 64 first downs, and have been penalized 36 times for a total of 345 yards. They have turned the ball over 5 times, with 9 passing touchdowns and 3 rushing touchdowns to their credit.

Defensively, the Cardinals have surrendered 1,184 passing yards, positioning them at 25th in the league. They allow an average of 236.8 passing yards per game with a completion percentage against of 63.3%. Additionally, they have given up 633 rushing yards in 5 games, allowing 14 passing touchdowns and 6 on the ground. On average, they concede 363.4 total yards per game, ranking 26th in the league, permitting 4.4 yards per carry and 126.6 rushing yards per game this season. The Cardinals are last in the league in terms of points allowed, averaging 32.4 points against per game.

The Rams enter this clash with a 2-3 record this season. In their most recent game, they lost 37-34 to the Buffalo Bills. Kyren Williams rushed 16 times for 49 yards, averaging 3.1 yards per carry. Puka Nacua led the Rams in receiving, catching 17 passes for 138 yards (8.1 yards per reception). Quarterback Matthew Stafford threw for 383 yards and 3 touchdowns with a completion rate of 40 out of 54, achieving a QB rating of 111.9 and no interceptions. Defensively, the Rams allowed 37 rushing attempts for 234 yards (6.3 yards per carry). The passing defense permitted a completion rate of 63.2%, yielding 202 yards on 12 completions out of 19 attempts. The Rams had a total of 454 yards, running 77 plays for an average of 5.9 yards per play, with a rushing average of 3.3 yards on 23 carries.

In terms of scoring ability, the Rams rank 15th in the league, averaging 23.8 points per game. This season, they have accumulated 1,538 passing yards, averaging 307.6 passing yards per game, which is the highest in the league. Their rushing average stands at 116.8 yards per contest, totaling 584 yards on the ground. Overall, the Rams rank first in the NFL in total yards per game at 424.4. Furthermore, their offense has contributed to 368 yards of penalties, ranking 7th for giving their opponents opportunities. They have registered 6 interceptions and 2 fumbles, while achieving 79 first downs.

On defense, the Rams allow 24.0 points per game, placing them at 20th in the league. They have conceded 8 passing touchdowns and allow an average of 156.8 passing yards per game, ranking 2nd overall. The Rams have permitted a total of 642 rushing yards (average of 128.4 yards per game) and 4 rushing touchdowns throughout the season. The defense ranks 8th in plays contested at 294, creating 5 turnovers (1 fumble and 4 interceptions) this season, yielding a total of 120 points.

Who will take the victory in today’s Cardinals vs. Rams NFL matchup against the spread?

Prediction: Bet on the Rams -13.5

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Pick: Los Angeles Rams -13.5
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