Indianapolis Colts vs Minnesota Vikings Preview, 10/25/2026 NFL Picks, Top Bets & Odds Week 7

Home » Indianapolis Colts vs Minnesota Vikings Preview, 10/25/2026 NFL Picks, Top Bets & Odds Week 7

  • Matchup: Indianapolis Colts vs Minnesota Vikings
  • Date: Sunday, October 25, 2026
  • Venue: U.S. Bank Stadium, Minneapolis, MN
  • Broadcast: CBS
  • Betting Line: Colts +6.5
  • Total Points: 41.5

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The undefeated Minnesota Vikings (5-0) are set to face off against the struggling Indianapolis Colts (2-4) at U.S. Bank Stadium this Sunday. The Colts are currently listed as 6.5-point underdogs according to Vegas odds, with a total points line set at 41.5.

Coming off a disappointing loss to the Tennessee Titans, where they were edged out 26-20, the Colts hold a record of 2-4 this season. In that game, Jonathan Taylor led the rushing attack with 21 carries for 94 yards (4.5 yards per carry). Keenan Allen was the standout receiver, achieving 82 yards on 8 receptions, averaging 10.3 yards per catch. Quarterback Daniel Jones completed 22 of 42 passes for 269 yards and 1 touchdown, but also recorded 2 interceptions, finishing with a QB rating of 60.5. Defensively, the Colts allowed 84 rushing yards on 23 attempts (3.7 yards per rush) and permitted 11 completed passes out of 22 attempts for 102 yards, achieving a 50% completion rate. Overall, they managed 399 total yards on 72 plays, with a notable run game that netted 165 yards on 30 carries (5.5 yards per attempt).

nfl predictions Jonathan Taylor Indianapolis Colts betting odds

So far this season, the Colts have accumulated 1,868 total yards. Their offense has generated 64 first downs, but they’ve also accumulated 30 penalties for 225 yards. In terms of scoring, Indianapolis has thrown for 4 touchdowns and rushed for 9 touchdowns. However, they have also turned the ball over 11 times (6 interceptions and 5 fumbles lost). They average 111.5 rushing yards per game, ranking them 16th in the league, and score an average of 24.0 points per game.

On the defensive side, the Colts have given up 1,372 passing yards, which places them 21st in the league. They allow about 228.7 passing yards per game, with a completion rate of 61.4%. In total, they have conceded 735 rushing yards through six games this season, giving up 10 passing touchdowns and 6 rushing touchdowns. They rank 24th in total yards allowed, giving up an average of 351.2 yards per game, and 27th in points allowed with 27.3 per contest.

The Vikings come into this matchup with a perfect record of 5-0, recently defeating the New Orleans Saints 23-13. Quarterback Kyler Murray recorded 229 passing yards (24 completions on 30 attempts) and 1 touchdown, posting a QB rating of 109.6 without throwing any interceptions. Running back Aaron Jones rushed for 113 yards on 25 carries, averaging 4.5 yards per attempt. Star receiver Justin Jefferson caught 6 passes for 79 yards (13.2 yards per catch). The Vikings’ ground game averaged 4.3 yards per carry, totaling 153 rushing yards on 36 attempts. Overall, Minnesota accumulated 364 yards on 66 plays (5.5 yards per play), while their pass defense allowed a completion rate of 64.0%, yielding 87 yards on 16 of 25 passing, and restricting the opponent to just 55 rushing yards on 17 attempts (3.2 yards per rush).

The Vikings average 283.0 yards per game, ranking them 27th in the league. They generate approximately 116.0 rushing yards per game, with total rushing yards at 580. Their offense has thrown 2 interceptions and lost 2 fumbles, recording 42 first downs. However, they rank last in the league for penalties, allowing 250 yards due to infractions. In terms of passing yards, the Vikings have thrown for a total of 835 yards this season, averaging 167.0 yards per game, placing them 29th in the league. They rank 22nd in scoring output, averaging 21.8 points per game.

Defensively, the Vikings are excelling, allowing only 12.8 points per game, which is the best in the league. They have conceded 3 passing touchdowns and an average of 173.2 passing yards per game, ranking 3rd in the league. Their run defense has allowed 433 rushing yards this season (averaging 86.6 yards per game) and only 2 rushing touchdowns. The Vikings’ defense is also leading the league with 281 plays and has generated 10 takeaways (4 forced fumbles and 6 interceptions), allowing a mere 64 points so far.

Can the Colts make a statement against the Vikings this Sunday?

Prediction: Take the Colts +6.5

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Pick: IndianapolisColts +6.5
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