- Matchup: Jacksonville Jaguars vs San Francisco 49ers
- Date: Sunday, September 28, 2025
- Venue: Levi’s Stadium, Santa Clara, CA
- Broadcast: FOX
- Betting Odds: 49ers favored by 3.5 points
- Total Points Over/Under: 47
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The Jacksonville Jaguars (2-1) are set to face the San Francisco 49ers (3-0) this Sunday at Levi’s Stadium. The 49ers are currently favored by 3.5 points, with the over/under total set at 47 points.
Coming into this game, the Jacksonville Jaguars hold a 2-1 record for the season. In their most recent outing, the Jaguars defeated the Houston Texans 17-10. Quarterback Trevor Lawrence completed 20 of 40 passes for a total of 222 yards, while recording a QB rating of 56.5 and one interception. Travis Etienne led the rushers with 16 carries for 56 yards, averaging 3.5 yards per attempt. Brenton Strange contributed significantly, averaging 10.2 yards per catch with 61 yards from 6 receptions. As a team, the Jaguars executed 24 rushing plays for 86 yards, which translates to an average of 3.6 yards per rush. Overall, Jacksonville played 64 offensive snaps and gained 291 total yards. On the defensive side, the Jaguars allowed 25 completions out of 38 attempts, yielding 184 passing yards and achieving a 65.8% completion rate. Against the run, Jacksonville gave up 87 yards on 19 carries, averaging 4.6 yards per rush.
This season, the Jaguars have accumulated 1,069 total yards. They have achieved 34 first downs, but have faced challenges with 26 penalties totaling 218 yards. In terms of touchdowns, Jacksonville has scored 4 through the air and 3 on the ground, while turning the ball over 4 times. Their rushing attack averages 141.7 yards per game, placing them 5th in the league. The Jaguars are also scoring an average of 23.3 points per game, marking their offense’s impact.
Defensively, the Jaguars rank 6th by allowing an average of 17.0 points per game. They are conceding 4.1 yards per carry and 82.7 rushing yards per contest. Against the pass, Jacksonville has given up 628 yards, ranking them 16th in the league, and are allowing 209.3 passing yards per game with a completion percentage of 60.2%. Their total defensive yardage averages 292.0 yards per game, placing them 10th in the NFL. They have surrendered 5 passing touchdowns and 1 rushing touchdown, allowing a total of 248 rushing yards in 3 games this season.
The San Francisco 49ers come into this matchup with an undefeated 3-0 record. In their latest game, they narrowly defeated the Arizona Cardinals 16-15. Quarterback Mac Jones threw for 284 yards on 27 completions out of 41 attempts, achieving a QB rating of 83.8 while throwing 1 interception and averaging 6.9 yards per pass. Running back Christian McCaffrey carried the ball 17 times for 52 yards, averaging 3.1 yards per attempt. Ricky Pearsall was a key target, catching 8 passes for 117 yards, averaging 14.6 yards per reception. The 49ers finished with 73 rushing yards on 20 carries, averaging 3.7 yards per rush. Overall, they registered 355 yards of offense on 61 plays, averaging 5.8 yards per play. Defensively, the 49ers allowed a completion percentage of 62.9%, yielding 154 passing yards on 22 completions out of 35 attempts. They gave up 106 rushing yards on 28 attempts, averaging 3.8 yards per carry.
In terms of scoring, the 49ers currently rank 23rd in the league, averaging 19.7 points per game. This season, they have recorded 814 passing yards and an average of 271.3 passing yards per game, ranking 1st in the league. Their rushing offense averages 89.7 yards per game, accumulating a total of 269 rushing yards. Collectively, the 49ers average 361.0 yards per game, placing them 7th in the NFL. They have incurred 170 penalty yards, ranking 21st in the league in terms of discipline. San Francisco has committed 3 interceptions and 1 fumble, while achieving 44 first downs.
On the defensive side, they have allowed 4 passing touchdowns and an average of 162.0 passing yards per game, ranking them 5th in the NFL. The 49ers have given up a total of 311 rushing yards (103.7 yards per game) along with 1 rushing touchdown. The defense has registered 3 turnovers this season and allowed a total of 49 points, ranking 3rd in the league with an average of 16.3 points allowed per game.
Which team will cover the spread in this Jaguars-49ers NFL match?
Prediction: Jaguars +3.5
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