- Matchup: Louisville Cardinals vs Pittsburgh Panthers
- Date: Saturday, September 27, 2025
- Venue: Acrisure Stadium, Pittsburgh, PA
- Broadcasting: ESPN2
- Betting Odds: Panthers (+3.5)
- Over/Under Total: 56
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The Louisville Cardinals (3-0) are heading to Acrisure Stadium on Saturday, September 27, 2025, to face the Pittsburgh Panthers (2-1). The Cardinals are entering this game as 3.5-point favorites, with the point total set at 56.
This season, the Louisville Cardinals boast an undefeated record of 3-0. Their most recent outing saw them defeat the Bowling Green Falcons with a score of 40-17. In that game, the Cardinals executed 62 plays, amassing a total of 439 yards. They ran the ball 29 times, netting 126 yards at an average of 4.3 yards per carry. Defensively, the Cardinals allowed 190 rushing yards on 29 attempts, averaging 6.6 yards per rush. They surrendered 11 completions on 21 attempts for 131 passing yards, achieving a completion percentage of 52.4%.
In terms of offensive performance, the Cardinals average 39.7 points per game (PPG). Their rushing attack figures at 156.0 yards per game, ranking them 76th in college football. Overall, Louisville has accumulated 1,245 total yards this season. The distribution of their touchdowns includes 3 aerial scores and 8 ground touchdowns. The Cardinals have recorded 61 first downs, with 23 penalties costing them 210 yards, along with 5 turnovers.
Defensively, the Cardinals have allowed 344 passing yards this season, placing them 4th in the nation. They permit an average of 114.7 passing yards per game and a completion percentage of 51.4%. Overall, they have given up 244.7 yards per game, ranking 16th nationally. Opposing offenses have scored 2 touchdowns through the air and 3 on the ground against them. Opponents are rushing for an average of 3.4 yards per attempt, totaling 130.0 rushing yards per game. In three games, the Cardinals have allowed 390 rushing yards and rank 29th in points allowed, averaging 16.0 PPG.
The Pittsburgh Panthers enter this matchup with a record of 2-1. In their last game, they suffered a 31-24 defeat against the West Virginia Mountaineers. In that contest, Pittsburgh faced 58 rushing attempts, yielding 174 yards (3.0 yards per rush). Their pass defense allowed a completion rate of 68.8%, conceding 260 yards on 22 of 32 passes. The Panthers amassed a total of 349 yards through 72 plays (averaging 4.8 yards per play) while rushing for a mere 1.4 yards per carry, totaling 46 yards on 34 attempts.
Pittsburgh’s offense averages 424.3 yards per game, which ranks 53rd in Division 1. The team has incurred 23 penalties, resulting in 216 yards lost, placing them 67th nationally for penalties. Their ground game averages 109.3 yards per game, totaling 328 yards for the season. They have thrown 3 interceptions with no fumbles lost, and have secured 58 first downs. On the scoring front, the Panthers rank 17th in college football, averaging 43.3 PPG. They have accumulated 945 passing yards this season, with a passing average of 315.0 yards per game, ranking them 19th in Division 1.
Pittsburgh’s run defense has allowed 243 total rushing yards (81.0 yards per game) and 4 rushing touchdowns throughout the season. Defensively, they’ve yielded 3 passing touchdowns and 202.7 passing yards per game, putting them 64th in college football. So far, they have allowed 57 total points. The Panthers have recovered 1 fumble and made 2 interceptions, participating in 216 defensive plays, ranking 40th nationally. They give up an average of 19.0 PPG, which places them 45th in the country.
Can the Cardinals triumph over the Panthers against the spread in today’s college matchup?
Prediction: Bet on the Cardinals -3.5
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