Buffalo Bills at Atlanta Falcons Week 6 Prediction, NFL Picks, Best Bets & Odds for 10/13/2025

Home » Buffalo Bills at Atlanta Falcons Week 6 Prediction, NFL Picks, Best Bets & Odds for 10/13/2025

  • Game: Buffalo Bills vs Atlanta Falcons
  • Date: Monday, October 13, 2025
  • Location: Mercedes-Benz Stadium, Atlanta, GA
  • Broadcast: ESPN
  • Odds-Point Spread: Falcons (+4)
  • Total-Over-Under: 48.5

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The Buffalo Bills (4-1) are set to face off against the Atlanta Falcons (2-2) at Mercedes-Benz Stadium on Monday night. The Falcons enter this game as 4-point underdogs, with the total points expected to be 48.5.

Currently holding a record of 4-1, the Buffalo Bills last faced the New England Patriots, suffering a narrow defeat of 23-20. Quarterback Josh Allen completed 22 of 31 attempts, accumulating 253 yards and throwing 2 touchdowns, alongside 1 interception for a rating of 103.3. Running back James Cook led the ground game with 49 yards on 15 carries, averaging 3.3 yards per rush. Dalton Kincaid was impressive in the receiving game, notching 108 yards on 6 receptions, averaging 18.0 yards per catch. The Bills attempted to run a total of 29 times, gaining 118 yards with an average of 4.1 yards per attempt. Overall, they managed 363 total yards on 60 plays. On defense, Buffalo allowed 22 completions on 30 attempts, totaling 267 passing yards, which equates to a completion rate of 73.3%. Against the run, the Bills permitted 71 yards on 22 carries, averaging 3.2 yards per run.

NFL predictions Bijan Robinson Atlanta Falcons best bet odds

For the season, the Bills have accumulated 1,979 total yards and secured 65 first downs, while incurring 36 penalties totaling 287 yards. In scoring terms, Buffalo has recorded 9 passing and 9 rushing touchdowns. With 4 total turnovers (2 interceptions and 2 fumbles), they boast an impressive average of 154.4 rushing yards, ranking them 2nd in the league. The team averages 30.6 points per game.

On the defensive side, the Bills rank 18th in the league for points allowed, giving up an average of 22.6 points per game. They permit 5.6 yards per rush and 145.6 rushing yards per game. Through the air, the Bills have allowed 770 yards, ranking them 2nd overall, with an average of 154.0 yards allowed and a completion rate of 64.7%. Overall, they contribute to 299.6 total yards against per game, positioning them 9th in the league, with 6 touchdown passes and 7 rushing touchdowns allowed. So far, they have given up 728 rushing yards across 5 games this season.

The Falcons enter this matchup with a record of 2-2. In their last outing, Atlanta emerged victorious over the Washington Commanders with a scoreline of 34-27. Running back Bijan Robinson carried the ball 17 times for 75 yards, averaging 4.4 yards per attempt. Wide receiver Drake London was the standout performer, catching 8 passes for 110 yards, averaging 13.8 yards per reception. Quarterback Michael Penix had a stellar performance, throwing for 313 yards on 20-26 passes along with 2 touchdowns and a quarterback rating of 126, although he did throw 1 interception. The Falcons’ rushing defense allowed 147 yards on 22 attempts, at an alarming average of 6.7 yards per carry. In the secondary, they allowed a 59.3% completion rate, yielding 147 yards on 16 out of 27 passing attempts. Atlanta managed a total of 435 yards on 63 plays, averaging 6.9 yards per play, while they rushed for 128 yards on 37 attempts, averaging 3.5 yards per carry.

In terms of scoring, the Falcons currently rank 26th in the NFL with an average of 19.0 points per game. Throughout the season, they have amassed 905 passing yards, averaging 226.3 per contest, which ranks 13th in the league. Additionally, Atlanta averages 136.5 rushing yards per game, totaling 546 rushing yards. Overall, they sit at 7th in professional football with an average of 362.8 yards per game. The Falcons have been hindered by 21 penalties accounting for 152 total yards, ranking them 31st in the league for self-inflicted wounds. They have recorded 3 interceptions and 2 fumbles, while achieving 46 offensive first downs.

On defense, they have allowed 5 passing touchdowns, ranking 1st in the NFL, by permitting just 135.0 passing yards per game. The Falcons have also given up a total of 436 rushing yards this season (109.0 yards per game), along with 2 rushing touchdowns. The defensive unit has achieved 6 turnovers, consisting of 3 forced fumbles and 3 interceptions. Altogether, they have allowed 86 points all season. The Falcons’ defense leads the league with 208 plays from scrimmage allowed. They currently concede an average of 21.5 points per game, placing them 15th in the NFL.

Who will take the victory in tonight’s matchup between the Bills and Falcons?

Pick: Go with the Falcons +4

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Pick: Atlanta Falcons +4
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