Chicago Cubs vs Milwaukee Brewers Game 5 Predictions, Picks, Best Bets & Odds

Home » Chicago Cubs vs Milwaukee Brewers Game 5 Predictions, Picks, Best Bets & Odds

  • Matchup: Chicago Cubs vs Milwaukee Brewers
  • Date: Saturday, October 11, 2025
  • Venue: American Family Field, Milwaukee, WI
  • Broadcast: TBS
  • Wagering Odds: Chicago (+162) Milwaukee (-196)

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The Chicago Cubs (92-70) are traveling to American Family Field on Saturday for Game 5 of the NLDS against the Milwaukee Brewers (97-65). The moneyline for this matchup positions the Cubs at +162 and the Brewers at -196, with a betting total set at 7 runs. Expected starters include Shota Imanaga for the Cubs and Jacob Misiorowski for the Brewers, though both teams may utilize multiple pitchers throughout the game.

MLB Picks and Predictions for Chicago Cubs

As a collective unit, the Chicago Cubs are averaging 4.9 runs per game, which places them 5th in the league. They have tallied 793 runs while maintaining a team on-base percentage (OBP) of .320. The Cubs have achieved 267 doubles and hit 223 home runs, notching 771 runs batted in and 1,371 hits this season, with a batting average of .249. Their slugging percentage stands at .430, and they have struck out 1,277 times while receiving 554 walks.

The Cubs hold a K/BB ratio of 3.12, and their pitching staff sports a combined WHIP of 1.18. Collectively, Chicago’s pitchers have allowed 202 home runs and 649 total runs this year (7th in MLB). The Cubs have conceded 1,284 hits (8.1 per 9 innings) and 605 earned runs, achieving a team earned run average (ERA) of 3.79 (8th in MLB). Their pitchers have struck out 1,265 batters while walking 405, with a FIP of 4.16 so far this season.

The Cubs have deployed 523 relievers throughout the season, inheriting 142 runners so far, with 33.8% of those scoring. Their bullpen has secured 44 saves but has also failed to convert 20 of 64 save opportunities, leading to a save rate of 68.8%. In 177 save situations, the Cubs bullpen has accumulated 110 holds (3rd in the league). Cubs pitchers have entered games with runners on base 101 times, participating in 158 high-leverage situations.

The Boston Red Sox have recorded 4,305 putouts this season, alongside 1,342 assists and 61 errors. Their fielding percentage is an impressive .989, ranking them 4th in professional baseball, with 117 double plays converted. The Cubs have successfully turned 71.9% of balls in play into outs in their 12,915 innings, putting them 2nd in the league.

Shota Imanaga has thrown 317 innings with a career total of 291 strikeouts. His ERA is 3.29 (116 ER allowed), and he holds a career WHIP of 1.009. Imanaga has conceded 266 hits (7.5 hits per 9 innings) and walked 54 batters. With a career win-loss record of 24-11, he has faced 1,261 hitters in the major leagues.

The Brewers boast a slugging percentage of .403 and score 4.98 runs per game (3rd in the league). They have recorded 265 doubles, drawn 564 walks, and scored 806 runs, alongside 166 home runs and 750 runs batted in. They have struck out 1,266 times (26th in MLB) and amassed 1,423 hits. Milwaukee’s OBP stands at .332 with a batting average of .258 for the season.

As a pitching staff, the Brewers have allowed 634 runs this season, holding a team ERA of 3.58 (574 earned runs surrendered). They have given up 168 home runs and allow 3.96 runs per 9 innings (3rd in the league). The Brewers’ team WHIP is 1.228, accompanied by a FIP of 3.91. They also have a K/BB ratio of 8.90 (1,432 strikeouts versus 534 walks), ranking 3rd in MLB for total hits allowed with 1,237.

The Milwaukee bullpen has an inherited score percentage of 31.7% out of 218 inherited runners. Their relievers have appeared in high-leverage situations 187 times and 145 times with base runners. The Brewers have garnered 107 holds and 21 blown saves in 66 save opportunities, achieving a save percentage of 68.2% and using 550 relievers this season. They have completed 45 saves out of those chances.

Over their 12,978 innings played, the Brewers showcase 70.9% defensive efficiency (5th in pro baseball). They have turned 122 double plays and maintain a fielding percentage of .987 (10th in the majors). This season, the Brewers have amassed 1,297 assists, committed 76 errors, and recorded 4,326 putouts.

In his brief MLB career, Misiorowski has surrendered 51 hits while compiling 87 strikeouts in 66 innings. With a career record of 5-3, he holds a 4.36 ERA and has allowed 7.0 hits per 9 innings pitched. His WHIP is 1.242, with a FIP of 4.3, alongside a K/BB ratio of 2.81 after facing 273 opponents in his career.

Who will claim victory in tonight’s MLB clash against the spread or moneyline?

Prediction: Bet on Chicago (+162)

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Pick: Chicago Cubs (+162)
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