- Matchup: Pittsburgh Panthers vs Syracuse Orange
- Event Date: Saturday, October 18, 2025
- Venue: JMA Wireless Dome, Syracuse, NY
- Broadcast: ACC Network
- Betting Odds: Orange (+11.0)
- Total Points Over/Under: 55.5
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This Saturday, October 18, 2025, the Syracuse Orange (3-3) are set to compete against the Pittsburgh Panthers (4-2) at the JMA Wireless Dome. The Pittsburgh Panthers enter the game as 11.0-point favorites, with the total points line set at 55.5.
The Panthers arrive with a 4-2 record this season. In their most recent game, Pittsburgh secured a victory over the Florida State Seminoles with a score of 34-31. In that matchup, the Panthers executed 42 rushing attempts for a total of 155 yards, averaging 3.7 yards per carry. They completed 71 plays for 476 total yards. Defensively, they permitted 16 successful passes on 23 attempts, giving up 245 yards and achieving a completion rate of 69.6%. Conversely, Pittsburgh’s defense allowed 170 rushing yards on 40 attempts, resulting in an average of 4.3 yards per carry allowed.
This season, the Panthers have compiled a total of 2,591 yards. In scoring terms, Pittsburgh has achieved 18 passing touchdowns and 9 rushing touchdowns, while handing the ball over to opponents 10 times. They’ve secured 126 first downs as an offense and been flagged 42 times for a total of 379 yards. Their rushing game averages 122.5 yards per game, placing them 105th nationally. In terms of scoring, the Panthers average 39.8 points per game.
The Syracuse Orange enter this game with a 3-3 record for the season. In their last outing, they suffered a defeat against the SMU Mustangs, losing 31-18. Syracuse closed that game with 389 yards on 78 plays, averaging 5.0 yards per play. They averaged 3.3 yards per rush, accumulating 110 rushing yards on 33 carries. Defensively, Syracuse allowed 28 rushing attempts for 76 yards (2.7 yards per rush), while their passing defense struggled, permitting a completion percentage of 83.3% and yielding 294 yards on 30 of 36 pass attempts.
On offense, the Orange rank 69th nationally with an average of 29.0 points per game. Syracuse averages 432.3 yards per game, placing them 37th in Division 1. This season, they’ve incurred penalties totaling 290 yards across 31 infractions, which ranks 103rd in college football for penalty yards. The Orange have thrown 7 interceptions, lost 5 fumbles, and secured 141 first downs. So far, they have recorded 1,924 passing yards and average 320.7 passing yards per game, ranking them 6th in college football. Their ground game produces an average of 111.7 rushing yards per game with a total of 670 rushing yards.
Defensively, the Orange give up an average of 29.8 points per game, ranking them 114th in Division 1. They have allowed a total of 946 rushing yards, averaging 157.7 yards per game, and 7 touchdowns on the ground. In the passing game, Syracuse has permitted 15 touchdowns and 291.2 yards per game, ranking them 131st in Division 1. Their defense has engaged in 441 plays this season, ranking 121st overall. They have forced 3 fumbles and recorded 4 interceptions, with a total of 179 points allowed this season.
Who will emerge as the victor in the Panthers vs. Orange college football game against the spread?
Expert’s Pick: Bet on the Panthers -11.0
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