- Matchup: Buffalo Bills vs. Carolina Panthers
- Date: Sunday, October 26, 2025
- Venue: Bank of America Stadium, Charlotte, NC
- Broadcast: FOX
- Betting Odds: Panthers (+7.5)
- Total Points Over/Under: 45.5
This page may include affiliate links at no extra cost to you, thanks for your support.
The Buffalo Bills (4-2) are set to travel to Bank of America Stadium this Sunday as they face the Carolina Panthers (4-3). The Panthers enter the game as 7.5-point underdogs, according to Las Vegas odds, and the total points line stands at 45.5.
Currently, the Buffalo Bills boast a 4-2 record this season. In their previous game, they faced off against the Atlanta Falcons, suffering a 24-14 defeat. Quarterback Josh Allen connected on 15 of 26 passes for 180 yards and threw for 2 touchdowns, finishing with a quarterback rating of 72.6 alongside 2 interceptions. James Cook was the standout rusher, carrying the ball 17 times for 87 yards, averaging 5.1 yards per carry. Khalil Shakir contributed with 33 yards from 3 catches, averaging 11.0 yards per reception. Overall, the Bills managed 134 rushing yards on 24 attempts, averaging 5.6 yards per carry. They executed a total of 50 plays, accumulating 291 yards. Defensively, the Bills allowed 20 completions on 32 attempts for 233 yards, achieving a completion percentage of 62.5%. They conceded 210 yards on the ground over 32 carries, averaging 6.6 yards allowed per rush.
This season, the Bills have recorded a total of 2,270 yards, achieving 73 first downs and incurring 44 penalties for 351 yards. When it comes to scoring, the Bills have tallied 11 passing touchdowns and 9 rushing touchdowns, with 6 giveaways (4 interceptions and 2 fumbles). They average 151.0 rushing yards per game, placing them first in the NFL in that category. The team averages 27.8 points per contest.
Defensively, the Bills rank 17th in the league, allowing an average of 22.8 points per game. They give up approximately 5.8 yards per rushing attempt and 156.3 rushing yards per game. In the air, they’ve allowed 1,003 yards, ranking second in the league, with an average of 167.2 passing yards allowed per game and a completion rate of 64.2%. Overall, the Bills permit an average of 323.5 yards per game, placing them 15th in the NFL, with 7 touchdowns allowed through the air and 9 on the ground. This season, they’ve relinquished 938 rushing yards over 6 games.
The Panthers head into this matchup with a record of 4-3. In their last outing, they secured a narrow victory, defeating the New York Jets 13-6. Bryce Young threw for 138 yards on 15 of 25 passing, boasting a quarterback rating of 88.4, and tossed 1 touchdown with no interceptions, averaging 5.5 yards per attempt. Rico Dowdle was effective on the ground, rushing 17 times for 79 yards at an average of 4.6 yards per carry. He also contributed in the passing game, with 1 catch for 17 yards. Carolina’s rushing attack averaged 3.5 yards per attempt, amassing 125 yards over 36 carries. The Panthers executed 68 plays for a total of 302 yards, averaging 4.4 yards per play. Defensively, they held opponents to a 47.1% completion rate, allowing 139 passing yards on 16 of 34 attempts, while giving up 81 rushing yards on 20 carries (4.1 yards per carry).
Offensively, the Carolina Panthers average 326.7 yards per game, ranking 19th in the league. They run for an average of 140.1 yards per game, totaling 981 rushing yards. The Panthers defense has recorded 5 interceptions and allowed 4 fumbles, achieving 78 first downs on offense. Their penalties have amounted to 350 yards, ranking them 27th in being penalized. This season, they have thrown for 1,306 yards, averaging 186.6 yards through the air, which places them 26th in the NFL. The Panthers rank 24th in points scored with an average of 20.7 per game.
On the defensive side, the Panthers allow 21.7 points per game, ranking them 13th in the NFL. They have given up 10 passing touchdowns and allow an average of 203.1 yards per game through the air, positioning them 10th in that category. Thus far, the Panthers have yielded 648 rushing yards (92.6 yards per game) and have allowed 5 rushing touchdowns. Their defense has participated in 391 plays, ranking 9th in the league, and has amassed 7 takeaways (1 fumble and 6 interceptions), yielding a total of 152 points.
Who will emerge victorious in tonight’s matchup between the Bills and Panthers?
Josh’s Prediction: Take the Panthers +7.5
Some links on this page are affiliate links. If you sign up or make a purchase through them, we may earn a small commission always at no extra cost to you. Thanks for helping us keep this site running.
