Prediction for Western Kentucky Hilltoppers vs LSU Tigers: College Football Picks, Best Bets & Odds on 11/22/2025

Home » Prediction for Western Kentucky Hilltoppers vs LSU Tigers: College Football Picks, Best Bets & Odds on 11/22/2025

  • Matchup: Western Kentucky Hilltoppers vs LSU Tigers
  • Scheduled Date: Saturday, November 22, 2025
  • Venue: Tiger Stadium, Baton Rouge, LA
  • Broadcasting On: SEC Network
  • Betting Odds: Tigers favored by 23.0 points
  • Total Points Over/Under: 50

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Tiger Stadium will host an exciting clash between the LSU Tigers (6-4) and the Western Kentucky Hilltoppers (8-2) on Saturday, November 22, 2025. The Hilltoppers enter this game as 23.0-point underdogs, according to oddsmakers. The total points for the game are projected at 50.

Currently boasting an 8-2 record, the Western Kentucky Hilltoppers come off a convincing win against the MTSU Blue Raiders, finishing 42-26. They ran a total of 79 plays, amassing 642 yards of offense. Rushing was a strong element for the Hilltoppers, as they executed 38 rushing plays for 271 yards, averaging 7.1 yards per carry. On defense, they allowed just 66 rushing yards on 26 attempts (2.5 yards per carry). In the passing game, the Hilltoppers permitted 13 completions out of 40 attempts for 112 yards, achieving a completion percentage of 32.5%.

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In terms of offensive output, the Hilltoppers average 31.3 points per game (PPG) and rank 92nd nationally with 136.8 rushing yards per game. For the season, they have totaled 4,329 yards of offense, scoring 21 touchdowns through the air and 16 on the ground. The team has recorded 225 first downs but has been hindered by 62 penalties that accumulated 627 yards. They have turned the ball over 14 times.

Defensively, the Hilltoppers have allowed 2,233 passing yards, ranking 73rd in the country. They give up an average of 223.3 passing yards per game, allowing a completion rate of 54.8%. In total, they yield 399.0 yards per game, placing them at 97th nationally. They have given up 8 passing touchdowns and 12 rushing touchdowns while allowing an average of 5.1 yards per carry and 175.7 rushing yards per game. In ten games, they yielded 1,757 rushing yards and sit 54th in team defense, allowing 23.1 points per contest.

The LSU Tigers enter this game with a record of 6-4. In their previous matchup, they secured a tight win over the Arkansas Razorbacks with a score of 23-22. LSU managed 4.2 yards per carry during that game, totaling 155 rushing yards on 37 attempts. As a unit, the Tigers accumulated 390 yards and executed 70 plays (5.6 yards per play). The Tigers’ secondary allowed a completion rate of 61.1%, giving up 288 yards on 22 of 36 passing. The defense restricted the Razorbacks to 56 rushing yards on 26 attempts (2.2 yards per carry).

Scoring-wise, the Tigers rank 98th in Division 1 with an average of 23.6 PPG and produce an average of 346.6 yards per game, also placing 98th in college football rankings. The offense has garnered 582 penalty yards from 69 infractions, ranking them 40th in Division 1 for mistakes. LSU has thrown 5 interceptions and lost 5 fumbles, achieving 198 first downs this season. They’ve accumulated 2,402 passing yards for an average of 240.2 yards per game, ranking 61st in Division 1, while their rushing game averages 106.4 yards per game with a total of 1,064 rushing yards.

On defense, LSU has allowed 1,309 rushing yards (130.9 yards per game) and 14 rushing touchdowns this year. Through the air, they’ve conceded 8 passing touchdowns and 198.2 yards per game, ranking 42nd nationally. Overall, they’ve allowed 193 points in total? The defense has also registered 4 fumbles and 12 interceptions this season, participating in 634 plays, which ranks them 30th in the nation. The Tigers’ defense is allowing 19.3 points per game, placing them 21st in Division 1.

Who will emerge victorious in this thrilling matchup between the Hilltoppers and Tigers?

Prediction: Bet on the Hilltoppers +23.0

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Pick: Western Kentucky Hilltoppers +23.0
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