- Matchup: Kentucky Wildcats vs. Vanderbilt Commodores
- Scheduled Date: Saturday, November 22, 2025
- Venue: FirstBank Stadium, Nashville, TN
- Broadcast: ESPN
- Betting Odds/Point Spread: Commodores favored by (-10.0)
- Total Points/Over-Under: 54
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The Kentucky Wildcats, holding a record of 5-5, will visit FirstBank Stadium on Saturday, November 22, 2025, as they aim to overcome the Vanderbilt Commodores, who have a strong 8-2 record. According to Las Vegas odds, Vanderbilt is favored by 10.0 points, with a total points line set at 54.
In their latest outing, the Kentucky Wildcats clinched a decisive victory against the Tennessee Tech Golden Eagles, finishing with a score of 42-10. The Wildcats carried the ball 39 times, amassing 207 rushing yards at an impressive average of 5.3 yards per attempt. Overall, Kentucky executed 66 plays, generating a total of 468 yards. On defense, they allowed 20 completions on 37 attempts, yielding 143 passing yards, which corresponds to a completion rate of 54.1%. Against the running game, the Wildcats permitted 104 yards on 32 carries, averaging 3.3 yards per rush.

Throughout this season, the Wildcats have generated a total of 3,638 yards. In their quest to find the end zone, Kentucky has recorded 13 touchdown passes and 19 rushing touchdowns, while turning the ball over 17 times. The Wildcats have gained 209 first downs and faced 47 penalties totaling 373 yards. With an average of 159.9 rushing yards per game, they currently rank 66th in the nation. Offensively, the Kentucky Wildcats score an average of 25.9 points per game.
Defensively, the Wildcats rank 55th in Division 1, allowing 23.1 points per game. They concede approximately 3.5 yards per run and have given up 128.8 rushing yards per contest this season, totaling 1,288 yards through 10 games. In the air, Kentucky has yielded 2,158 passing yards, placing them 57th nationally, and they allow 215.8 yards per game with a completion percentage of 58.7%. On average, they permit 344.6 total yards per game, ranking 50th in the country, with 8 passing touchdowns and 17 rushing touchdowns given up.
The Vanderbilt Commodores come into this matchup with an impressive 8-2 record this season. They recently triumphed over the Auburn Tigers with a nail-biting score of 45-38. In that game, Vanderbilt allowed 36 rushing attempts for 210 yards (an average of 5.8 yards per carry). Their secondary struggled, giving up a completion percentage of 67.4%, surrendering 353 yards on 31 out of 46 passes. The Commodores recorded a total of 544 yards while running 69 plays, averaging 7.9 yards per play. On the ground, they rushed for 4.6 yards per carry, ending the contest with a total of 167 yards from 36 attempts.
The Vanderbilt Commodores are averaging 443.6 total yards per game, ranking them 24th in Division 1. Their offense has drawn 617 penalty yards through 67 infractions, placing them 47th nationally. They average 185.2 rushing yards per game, having rushed for a total of 1,852 yards this season. The Commodores have thrown 5 interceptions and lost 4 fumbles, while achieving 235 first downs. With an average of 38.3 points per game, Vanderbilt stands at 9th in Division 1 scoring. They have accumulated 2,584 passing yards this season, averaging 258.4 yards per game, ranking them 40th in college football.
Defensively, Vanderbilt has surrendered 1,125 rushing yards (112.5 yards/game) and 6 rushing touchdowns this season. They have also allowed 19 touchdowns through the air, averaging 244.7 yards per game, ranking them 106th nationally. This season, the Commodores have given up a total of 222 points. They have recovered 7 fumbles and intercepted 4 passes. With 638 defensive plays executed, they rank 32nd in the country, allowing an average of 22.2 points per game, placing them 48th overall.
Which team will prevail in the Wildcats vs. Commodores college football game against the spread?
Prediction: Bet on the Commodores -10.0
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