Michigan State Spartans vs Iowa Hawkeyes Forecast, 11/22/2025 College Football Selections, Top Wagers & Odds

Home » Michigan State Spartans vs Iowa Hawkeyes Forecast, 11/22/2025 College Football Selections, Top Wagers & Odds

  • Matchup: Michigan State Spartans vs Iowa Hawkeyes
  • Date: Saturday, November 22, 2025
  • Venue: Kinnick Stadium, Iowa City, IA
  • Broadcast: FS1
  • Point Spread: Hawkeyes favored by 16.5 points
  • Over/Under: 43 points

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Kinnick Stadium will host an exciting clash on Saturday, November 22, 2025, featuring the Iowa Hawkeyes (6-4) taking on the Michigan State Spartans (3-7). The Spartans enter this matchup as 16.5-point underdogs according to sportsbooks. The total points line has been set at 43.

The Michigan State Spartans come into this game with a disappointing 3-7 record. In their previous outing, they faced off against the Penn State Nittany Lions but fell short with a score of 28-10. During that game, Michigan State attempted 22 runs, accumulating 101 rushing yards at an average of 4.6 yards per carry. Overall, they ran 49 plays, amassing a total of 229 yards. Defensively, the Spartans allowed the Nittany Lions to complete 26 of 39 passes for 197 yards, leading to a 66.7% completion rate. On the ground, they surrendered 104 rushing yards on 23 carries, averaging 4.5 yards per carry.

Michigan State Spartans College Football Picks and Predictions

In terms of offensive performance, the Michigan State Spartans are averaging 24.0 points per game this season. Their rushing attack averages 123.3 yards, ranking them 104th nationally. To date, they have accumulated 3,358 total yards. In the red zone, Michigan State has successfully thrown 14 touchdowns and rushed for 16. They have achieved 184 first downs while committing 56 penalties totaling 484 yards and turning the ball over 10 times.

On the defensive side, the Spartans have allowed 2,170 passing yards, ranking 63rd in Division I football. Their opponents have averaged 217.0 passing yards per game against them with a completion rate of 67.6%. Overall, Michigan State’s defense has given up 370.9 yards per game, placing them 69th in the nation. They have conceded 19 touchdowns through the air and 20 on the ground, allowing an average of 4.5 yards per carry and totaling 153.9 rushing yards allowed per game. Over 10 games, they have conceded 1,539 rushing yards, putting them 115th in college football regarding opponent scoring, allowing an average of 31.1 points per game.

The Iowa Hawkeyes enter this contest with a record of 6-4. Their last game resulted in a 26-21 defeat against the USC Trojans. In that matchup, Iowa accumulated 320 total yards from 53 plays, averaging 6.0 yards per play. On the ground, they rushed for 183 yards on 33 carries, averaging 5.5 yards per attempt. Defensively, the Hawkeyes allowed 106 rushing yards on 31 attempts, averaging 3.4 yards per rush, while the passing defense recorded a completion percentage of 71.9%, yielding 254 yards on 23 of 32 passes.

Regarding offensive production, the Hawkeyes rank 62nd in the nation with an average of 28.7 points per game. They achieve an average of 310.2 total yards per game, placing them 118th nationally. The Iowa offense has incurred 253 yards in penalties across 26 infractions, ranking 136th in D-1 for mistakes. They have thrown 6 interceptions while allowing opponents to recover 3 fumbles, securing 174 first downs so far. For the season, the Hawkeyes have recorded 1,336 passing yards, averaging just 133.6 yards per game, placing them 132nd in Division I. Their rushing attack averages 176.6 yards per game, totaling 1,766 rushing yards for the season.

Defensively, the Hawkeyes are impressive, allowing just 14.9 points per game, ranking them 9th in college football. They have conceded a total of 1,038 rushing yards, averaging 103.8 yards per game, and have given up 10 rushing touchdowns. In terms of passing defense, they have yielded 5 touchdowns and 157.4 yards per game, ranking them 6th nationally. The Iowa defense has been active on the field for 589 plays, which ranks them 5th nationally, contributing to their total of just 149 points allowed this season.

Who will emerge victorious in this highly anticipated college football battle between the Spartans and Hawkeyes?

Prediction: Bet on the Spartans +16.5

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Pick: Michigan State Spartans +16.5
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