- Matchup: Carolina Panthers vs San Francisco 49ers
- Date: Monday, November 24, 2025
- Venue: Levi’s Stadium, Santa Clara, CA
- Broadcast: ESPN
- Betting Odds: 49ers (-7)
- Total Points: 48.5
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The Carolina Panthers (6-5) are set to face off against the San Francisco 49ers (7-4) at Levi’s Stadium this coming Monday. The 49ers kick off as 7-point favorites according to Las Vegas odds. The total points line is set at 48.5.
Entering this game, the Panthers stand at 6-5 for the season. In their previous outing, Carolina triumphed over the Atlanta Falcons with a final score of 30-27. Quarterback Bryce Young completed 31 of 45 passes for 448 yards, throwing for three touchdowns, achieving a quarterback rating of 123.2, and notably, he had no interceptions. Rico Dowdle led the ground game for the Panthers, carrying the ball 19 times for 45 yards, averaging 2.4 yards per attempt. Receiver Tetairoa McMillan had an impressive performance, averaging 16.3 yards per catch, totaling 130 yards on 8 receptions. As a team, the Panthers rushed the ball 25 times for a total of 67 yards, averaging 2.7 yards per carry. Overall, they ran 70 plays, accumulating 486 yards. Defensively, they allowed 19 completions on 30 passing attempts for 223 yards, boasting a completion percentage of 63.3%. On the ground, the Panthers surrendered 125 yards on 28 attempts, averaging 4.5 yards per rush.
Offensively, the Carolina Panthers are scoring an average of 18.8 points per game. They rank 9th in the league for rushing yards, averaging 127.1 yards per game, totaling 3,457 yards this season. Carolina has registered 121 first downs but has faced struggles with 60 penalties totaling 463 yards. They have committed 15 turnovers (8 interceptions and 7 fumbles lost). In terms of touchdown production, the Panthers have thrown for 15 passing touchdowns and scored 7 rushing touchdowns.
Defensively, the Panthers rank 13th overall, allowing an average of 22.6 points per game. They give up 4.4 yards per rush and average 113.1 rushing yards allowed per game. In terms of passing defense, Carolina has conceded 2,341 yards, ranking them 22nd in the NFL, with 212.8 passing yards given up per game and a completion rate of 64.6%. Overall, they are allowing 325.9 yards per game, placing them 15th in the league. The Panthers have yielded 13 passing touchdowns and an additional 13 rushing touchdowns, with a total of 1,244 rushing yards allowed throughout the season.
The San Francisco 49ers enter this game with a 7-4 record this season. In their last game, the 49ers secured a decisive win against the Arizona Cardinals, finishing 41-22. Running back Christian McCaffrey carried the ball 13 times for 81 yards, clocking in at 6.2 yards per carry. George Kittle led the receiving corps with 6 receptions for 67 yards, averaging 11.2 yards per catch. Quarterback Brock Purdy threw for 200 yards on 19 of 26 passes, achieving a quarterback rating of 133.5 with three touchdowns and no interceptions. The team allowed only 36 yards on 14 rushing attempts (2.6 yards per carry). Additionally, the 49ers’ passing defense yielded 452 yards on 47 completions out of 57 attempts, translating to a completion rate of 82.5%. San Francisco’s offense recorded a total of 281 yards over 51 plays, averaging 5.5 yards per play. They finished with 95 rushing yards across 25 attempts, averaging 3.8 yards per carry.
San Francisco averages 349.4 total yards per game, ranking 10th in the league. They average 94.8 rushing yards per game, with a season total of 1,043 rushing yards. The team has thrown 10 interceptions this season and lost 5 fumbles, registering 152 first downs. The 49ers’ offense has contributed to 482 yards lost to penalties, ranking 23rd in the league in that category. Through the air, San Francisco has accrued 2,800 yards this season, averaging 254.5 yards per game and standing at 2nd in the league. In terms of scoring, they rank 15th overall with an average of 23.7 points per game.
Defensively, the 49ers allow an average of 22.9 points per game, placing them 15th in the league. They have surrendered 21 passing touchdowns and an average of 249.1 passing yards per game, ranking 28th in the NFL. San Francisco has allowed a total of 1,142 rushing yards, averaging 103.8 yards per game, along with 8 rushing touchdowns this year. They have participated in 687 defensive plays, ranking 31st in the league, and have made 10 takeaways this season (7 forced fumbles and 3 interceptions). In total, the defense has given up 252 points.
Who will emerge victorious in this Panthers-49ers NFL showdown against the spread?
Expert Prediction: Back the 49ers -7
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