- Matchup: Syracuse Orange vs. Notre Dame Fighting Irish
- Date: Saturday, November 22, 2025
- Venue: Notre Dame Stadium, Notre Dame, IN
- Broadcast: NBC Peacock
- Point Spread: Fighting Irish favored by 35.0
- Total Points Over/Under: 50.5
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On Saturday, November 22, 2025, Notre Dame Stadium will host a clash between the Syracuse Orange (3-7) and the Notre Dame Fighting Irish (8-2). Oddsmakers have installed the Fighting Irish as 35.0-point favorites, with an over/under set at 50.5 points.
The Syracuse Orange are entering this game with a 3-7 record this season. In their previous outing, they faced the Miami Hurricanes and suffered a defeat, finishing 38-10. During that game, Syracuse executed 71 plays, racking up 285 total yards. They rushed 43 times for 161 yards, averaging 3.7 yards per carry. On the defensive side, they allowed 124 yards on 32 attempts, which translates to an average of 3.9 yards per carry. In the passing game, Syracuse gave up 261 yards on 19 completed passes out of 25 attempts, resulting in a completion percentage of 76.0%.

In terms of total offense, the Orange have accumulated 3,624 yards this season. They’ve scored 17 touchdowns through the air and 10 on the ground, while turning the ball over 20 times. Syracuse has achieved 203 first downs and faced 61 penalties totaling 542 yards. Their rushing offense averages 117.7 yards per game, placing them at 113th in Division 1. Scoring-wise, the Syracuse Orange average 22.3 points per game.
Defensively, Syracuse has surrendered 2,670 passing yards this season, ranked 121st in Division 1. They allow an average of 267.0 passing yards per game with a completion rate of 66.3%. Overall, they are giving up 430.4 total yards per contest, which puts them at 125th nationally. They have allowed 22 passing touchdowns and 14 rushing touchdowns, with an average of 4.7 yards per carry and 163.4 rushing yards per game. This season, they’ve given up 1,634 rushing yards over 10 games, ranking 117th nationally in team defense with an average of 31.5 points against per game.
The Fighting Irish are heading into this matchup with an 8-2 record this season. Their last game resulted in a commanding victory, where they triumphed over the Pittsburgh Panthers with a score of 37-15. Notre Dame allowed 45 rushing attempts for 206 yards (4.6 yards per rush). In pass defense, they recorded a completion rate of 30.0%, yielding only 22 yards on 3 out of 10 attempts through the air. The Fighting Irish finished the game accumulating 387 yards on 68 plays (5.7 yards per play), while rushing for 4.9 yards per carry with a total of 175 yards on 36 attempts.
In scoring efficiency, the Fighting Irish rank 8th in college football with an average of 38.5 points per game. They accumulate 458.2 yards per game, which places them 18th in Division 1. Their offense has committed 532 yards of penalties on 58 infractions, ranking 89th for mistakes. They’ve thrown 6 interceptions and lost 4 fumbles, while collecting 231 first downs. Throughout the season, the Fighting Irish have amassed 2,657 passing yards, averaging 265.7 passing yards per game, which stands 30th in the nation. Their rushing game averages 192.5 yards, yielding a total of 1,925 rushing yards overall.
Defensively, Notre Dame allows an average of 18.4 points per game, ranking them 18th in Division 1. They have given up a total of 993 rushing yards (99.3 yards per game) and 7 rushing touchdowns this season. In pass defense, they’ve allowed 12 touchdowns through the air and 224.0 yards per game, ranking them 78th in the country. The Fighting Irish defense has been on the field for 665 plays, which ranks 65th nationally. Overall, they’ve forced 2 fumbles and collected 17 interceptions, allowing a total of 184 points this season.
Who will emerge victorious in today’s Syracuse vs. Fighting Irish football game against the spread?
Recommendation: Bet on the Orange +35.0
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