Chicago White Sox vs Cleveland Guardians Preview, 9/12/2025 MLB Predictions, Top Picks & Odds

Home » Chicago White Sox vs Cleveland Guardians Preview, 9/12/2025 MLB Predictions, Top Picks & Odds
  • Matchup: Chicago White Sox vs Cleveland Guardians
  • Date: Friday, September 12, 2025
  • Venue: Progressive Field, Cleveland, OH
  • Broadcast: CLEGuardians.TV
  • Betting Odds: Chicago (+126) Cleveland (-152)

The Chicago White Sox (56-90) are set to face off against the Cleveland Guardians (74-71) at Progressive Field this Friday. The moneyline has Chicago at +126, while Cleveland comes in at -152. The total runs line for this game is set at 8. The starting pitchers are Martin Perez and Tanner Bibee.

MLB predictions for Steven Kwan and Cleveland Guardians

At the plate, the White Sox boast a slugging percentage of .379, having struck out 1,218 times while drawing 457 walks. They’ve recorded 572 RBIs along with 1,146 hits, yielding a batting average of .236. The squad has compiled 227 doubles and 150 home runs this season, accruing 592 runs with an on-base percentage (OBP) of .305. On average, the Chicago White Sox score 4.1 runs per game, placing them 26th in the MLB.

The White Sox have a strikeout-to-walk ratio of 2.11, with a pitching staff holding a WHIP of 1.37. Their pitchers have allowed 166 home runs, contributing to a total of 672 runs (21st in MLB). Chicago has given up 1,204 hits this season (8.5 per 9 innings) and has 603 earned runs against them, resulting in an ERA of 4.25 (20th in the league). Their pitching staff has struck out 1,141 batters, while the walk count stands at 542, leading to a FIP of 4.48 for the season.

The White Sox’s bullpen has entered games with runners on base 147 times, with a total of 140 appearances in high-leverage scenarios. They’ve secured 63 holds this year (27th in the league) and achieved a save percentage of 52.3%. So far, they have converted 23 out of 44 save opportunities. Relievers have inherited 214 base runners for the season, with 32.2% of those runners scoring. Chicago has utilized 475 relief pitchers throughout the campaign.

The Chicago Cubs have recorded 3,835 putouts, along with 1,160 assists and 95 errors this season. Their current fielding percentage stands at .981, ranking 28th in Major League Baseball, and they have completed 117 double plays. The White Sox converted 69.7% of balls in play into outs across their 11,505 innings on the field, sitting at 16th in the majors.

Perez holds a career win-loss record of 91-91 with a FIP of 4.34 against 7,028 batters faced throughout his career. He’s allowed 1,741 hits (9.7 hits per 9 innings) and has walked a total of 586 batters. His career ERA is 4.41, having allowed 794 earned runs and maintaining a WHIP of 1.436. Perez has pitched for 1,620 innings and achieved 1,148 strikeouts to date.

The Guardians have a team slugging percentage of .370 and are averaging 3.91 runs per game (27th in baseball). With 211 doubles, they’ve drawn 444 walks resulting in 567 runs scored. Cleveland has launched 148 home runs this season, contributing to 547 RBIs. They have struck out 1,204 times (17th in the league) and amassed 1,072 hits, earning an OBP of .297 and a batting average of .225 this year.

The Guardians’ pitching staff has a WHIP of 1.303 and a collective FIP of 4.10. Their strikeout-to-walk ratio stands at 8.40 (1,195 strikeouts to 491 walks). Cleveland ranks 14th in MLB for total hits allowed with 1,187, having given up 155 home runs and 4.23 runs per 9 innings (11th in the league). The team has allowed 606 runs so far this season, resulting in an ERA of 3.87 (554 earned runs allowed).

The Guardians’ bullpen has stepped in for 61 save opportunities and has a success rate of 42 saves. They rank 5th in the league with a save percentage of 68.9% and have used 475 relief pitchers this season. Their relievers have appeared 167 times in high-pressure situations and 134 times with runners on base. The inherited runners that score rate is 33.7% out of 187 total.

Cleveland has completed 112 double plays with a fielding percentage of .983 (27th in MLB). The Guardians have achieved 1,198 assists, committed 89 errors, and made 3,864 putouts for the year. With 11,592 innings played, they maintain a defensive efficiency of 69.5% (19th in MLB).

Bibee has allowed 431 hits during his MLB tenure, accompanied by 467 strikeouts over 476 innings. With a career record of 31-23, he maintains a 3.74 earned run average while permitting 8.1 hits per 9 innings. He has given up a total of 198 earned runs, with a WHIP of 1.197 and a FIP of 3.7. His K/BB ratio stands at 3.36, and he has faced 1,979 opposing batters.

Who emerges victorious in tonight’s MLB face-off against the spread or moneyline?

Tony Sink’s Recommendation: Back Chicago (+126)

 


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Pick: Chicago White Sox (+126)
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