St. Louis Cardinals versus Milwaukee Brewers Prediction, 9/12/2025 MLB Picks, Top Bets & Odds

Home » St. Louis Cardinals versus Milwaukee Brewers Prediction, 9/12/2025 MLB Picks, Top Bets & Odds

Matchup: St. Louis Cardinals vs Milwaukee Brewers

Date: Friday, September 12, 2025

Venue: American Family Field, Milwaukee, WI

Broadcast: FanDuel Sports Network Wisconsin

Betting Odds: St. Louis (+125) Milwaukee (-150)

The Milwaukee Brewers (89-58) are set to face off against the St. Louis Cardinals (72-75) at American Family Field this Friday. Current odds place the Cardinals at +125 and the Brewers at -150, with an over/under of 9 runs. The starting pitchers will be Andre Pallante and Quinn Priester.

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The St. Louis Cardinals are averaging 4.3 runs per game, ranking them 22nd in Major League Baseball. They’ve recorded a total of 629 runs with an on-base percentage of .313. The Cardinals have hit 234 doubles and launched 138 home runs, driving in 599 runs with a collective batting average of .244. Their slugging percentage stands at .379, and they’ve been struck out 1,185 times while managing to draw 433 walks this season.

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The Cardinals have compiled a team ERA of 4.26 this season (21st in MLB), with their pitchers striking out a total of 1,086 batters. Opponents have hit 151 home runs against them, contributing to 675 total runs allowed (22nd overall). The pitching staff has walked 415 batters, with a combined FIP of 4.04 for the season. St. Louis has given up 1,293 hits (averaging 9.0 hits per 9 innings) alongside 615 earned runs. Their strikeout-to-walk ratio is 2.62, and their WHIP stands at 1.31.

Cardinal relievers boast a save percentage of 65.5%, having faced 143 save situations. They inherited 195 runners, with 32.8% crossing home plate. St. Louis pitchers entered games with runners on base 141 times and appeared in 140 high-leverage situations. The team has utilized 434 relief pitchers this season, accumulating 82 holds (ranked 14th in the league) and converting 38 saves out of 58 opportunities.

In terms of defense, the Cardinals have converted 69.1% of balls in play into outs over 11,706 innings, placing them 21st in the major leagues. They’ve recorded 3,902 putouts, 1,414 assists, and 71 errors this season, holding a fielding percentage of .987 (11th in professional baseball) and turning 116 double plays.

Pallante (24-27 win-loss record) holds a FIP of 4.22 after facing 1,923 batters during his MLB career. He surrendered 460 hits (9.3 hits per 9 innings) along with 171 walks, with an earned run average of 4.29 (213 earned runs). His career spans 447 innings, with 314 strikeouts to his name.

On the other hand, the Milwaukee Brewers have recorded 157 home runs and driven in 689 runs this season. They’ve accumulated 239 doubles, drawn 504 walks, and scored 743 runs. The Brewers hold an on-base percentage of .333 and a batting average of .260. They’re averaging 5.05 runs per game, ranking 3rd in MLB, while being struck out 1,147 times as they compile 1,300 hits.

The Brewers have a team WHIP of 1.232 and a combined FIP of 3.92 for the year, ranking 3rd in total hits allowed with 1,124 hits conceded. Their pitching staff has allowed 576 runs, compiling a team ERA of 3.63 with 527 earned runs. Milwaukee’s strikeout-to-walk ratio is an impressive 8.90 (1,290 strikeouts against 485 walks), allowing 152 home runs and surrendering just 3.97 runs per 9 innings (4th in MLB).

With 165 save chances, the Brewers have registered 100 holds and encountered 19 blown saves. Their relievers have been called upon in 61 save situations, converting 42 saves. The bullpen has taken the mound 169 times in crucial situations and faced base runners 129 times. Milwaukee’s relief pitching has an inherited runner scoring percentage of 29.7% among 192 inherited base runners, ranking 6th in save percentage (68.9%). They’ve utilized 494 relief pitchers this year.

The Milwaukee Brewers have recorded 107 double plays this season, maintaining a fielding percentage of .987 (9th in baseball). They’ve tallied 1,172 assists, made 65 errors, and earned a total of 3,920 putouts over 11,760 innings, boasting a defensive efficiency of 70.9% (4th in MLB).

Priester, in his professional career, has allowed 242 hits while racking up 182 strikeouts across 240 innings. With an 18-11 win-loss record, he carries a 4.49 earned run average, permitting 9.1 hits per 9 innings. He’s given up 120 earned runs, maintaining a WHIP of 1.369 and a FIP of 4.4. His K/BB ratio stands at 2.09 after facing 1,041 batters in the majors.

Who will emerge victorious in tonight’s MLB matchup against the spread or moneyline?

Parlay’s Pundit’s Prediction: Bet on Milwaukee (-150) and the under 9 runs

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