St. Louis Cardinals vs. Milwaukee Brewers Insights, 9/25/2026 MLB Picks, Top Bets & Odds

Home » St. Louis Cardinals vs. Milwaukee Brewers Insights, 9/25/2026 MLB Picks, Top Bets & Odds

  • Matchup: St. Louis Cardinals vs Milwaukee Brewers
  • Date: Friday, September 25, 2026
  • Venue: American Family Field, Milwaukee, WI
  • Broadcast: Brewers.TV
  • Betting Odds: St. Louis (+110) Milwaukee (-132)

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On Friday, American Family Field will host the showdown between the Milwaukee Brewers (98-59) and the St. Louis Cardinals (76-81). The moneyline for this matchup sets St. Louis at +110 and Milwaukee at -132, with a total of 8 runs predicted. The starting pitchers for this game are Michael McGreevy and Robert Gasser.

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The Cardinals have collectively achieved 226 doubles and recorded 161 home runs this season. St. Louis boasts a slugging percentage of .380, with 1,248 strikeouts and 498 walks throughout the season. As a team, they average 4.5 runs per game, placing them 13th in Major League Baseball. Their overall stats include 681 RBIs, 1,278 hits, and a batting average of .241, along with 704 runs scored and a on-base percentage of .314.

The Cardinals pitch with a K/BB ratio of 2.27 and a combined WHIP of 1.35. Their pitching staff has allowed 155 home runs and 729 runs overall, ranking them 22nd in MLB. St. Louis has given up 1,350 hits (8.7 per nine innings) and 667 earned runs, posting a team ERA of 4.28, which is the 21st in the league. They’ve recorded 1,239 strikeouts while allowing 547 walks, and their FIP stands at 4.10 for the season.

Cardinals relievers have been called into action with runners on base 164 times and have participated in 195 high-leverage situations, achieving 96 holds (8th in the league). They maintain a save rate of 60.5%, with 176 opportunities and have secured 46 saves out of 76 chances. This season, their bullpen has managed 239 inherited runners with 40.6% crossing home plate. In total, 534 different relievers have taken the mound this year.

In terms of defensive performance, the St. Louis Cardinals have accumulated 4,205 putouts, 1,473 assists, and 74 errors this season. Their fielding percentage is .987, placing them 9th in the majors, and they have successfully turned 149 double plays. The Cardinals convert 69.0% of the balls in play into outs during their 12,615 innings, ranking them 24th in MLB.

McGreevy, with a career record of 18-13, has a FIP of 3.83 after facing 1,163 batters in the majors. He’s surrendered 275 hits (8.8 per nine innings) and issued 68 walks, while his ERA is 3.89 (allowing 122 earned runs). With 282 innings pitched, he has tallied 189 strikeouts in his MLB career.

On the other side, the Milwaukee Brewers achieve a team on-base percentage of .340 and a batting average of .258. They have recorded 1,338 strikeouts (ranking 11th in MLB) and notched 1,375 hits this season. The Brewers have hit 149 home runs and accumulated 762 RBIs, boasting a team slugging percentage of .402 while scoring an average of 5.13 runs per game, one of the highest in MLB.

Milwaukee’s pitching staff carries a WHIP of 1.189 and has a FIP of 3.72. Their strikeout to walk ratio stands at 9.60 (1,496 strikeouts against 503 walks). They are ranked 2nd in the league for the fewest hits allowed, with a total of 1,163, yielding 166 home runs and 3.89 runs per 9 innings (4th in the league). So far this year, the Brewers have given up 606 runs, maintaining a team ERA of 3.55 (553 earned runs).

In save situations, Milwaukee has managed to accumulate 82 holds with 20 blown saves this season. They have called upon their relievers in 71 save opportunities, converting 51 into saves. The bullpen’s inherited run scoring average is 37.8% from 185 runners, with 155 high-leverage situations. They rank 7th in MLB for save percentage at 71.8%, fielding 492 relievers so far in the season.

The Milwaukee Brewers have successfully turned 117 double plays, boasting a fielding percentage of .987 (8th in MLB) with statistics including 1,234 assists, 70 errors, and 4,205 putouts through this campaign. Their defensive efficiency stands at 70.9%, placing them 8th in the league.

Gasser holds a 7-7 win-loss record with a 3.70 ERA, allowing 8.4 hits per nine innings. His strikeout to walk ratio is at 2.95 after facing 586 batters in his MLB career. He has allowed 56 earned runs, holding a WHIP of 1.218 and a FIP of 3.6. In 136 innings pitched throughout his career, Gasser has allowed 127 hits while recording a total of 115 strikeouts.

Who will prevail in tonight’s MLB contest against the spread or moneyline?

Recommendation: Choose Milwaukee (-132)

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Pick: Milwaukee Brewers (-132)
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