Purdue Boilermakers vs Notre Dame Fighting Irish Prediction for 9/20/2025 College Football Picks, Best Bets & Odds

Home » Purdue Boilermakers vs Notre Dame Fighting Irish Prediction for 9/20/2025 College Football Picks, Best Bets & Odds

Matchup: Purdue Boilermakers vs. Notre Dame Fighting Irish

Date: Saturday, September 20, 2025

Venue: Notre Dame Stadium, Notre Dame, IN

Broadcast: NBC Peacock

Point Spread: Fighting Irish favored by 27.0 points

Combined Total: 55.5

The Purdue Boilermakers (2-1) are set to clash with the Notre Dame Fighting Irish (0-1) on Saturday, September 20, 2025, at the iconic Notre Dame Stadium. Oddsmakers have established the Fighting Irish as 27.0-point favorites in this matchup, with a total set at 55.5.

As the season unfolds, the Boilermakers enter this contest with a 2-1 record. In their most recent game, they faced off against the USC Trojans, suffering a 33-17 defeat. Defensively, Purdue struggled against the run, allowing 178 yards on 40 attempts, which amounts to 4.5 yards per rush. In the passing game, they conceded 17 completions out of 28 attempts for 282 yards, reflecting a completion rate of 60.7%. Overall, the Boilermakers managed 67 plays, accumulating 357 total yards. On the ground, Purdue ran the ball 28 times but could only muster 52 yards, averaging just 1.9 yards per carry.

College Football Predictions | Eli Raridon | Notre Dame Fighting Irish

In terms of offensive scoring, the Boilermakers average 27.3 points per game. On the ground, they accumulate an average of 119.7 rushing yards, placing them 109th in the nation. For the season, Purdue has amassed 1,174 total yards. They have found the end zone with a balanced attack, recording 5 passing touchdowns and 5 rushing touchdowns. The team has garnered 75 first downs and has faced 10 penalties amounting to 115 yards. Additionally, they have turned the ball over 4 times.

Defensively, Purdue ranks 41st nationally in points allowed, surrendering an average of 16.7 points per game. Their opponents are averaging 3.7 yards per carry and 125.0 rushing yards per game. Over three games, they have given up a total of 375 rushing yards. In the air, Purdue has allowed 571 yards, positioning them 60th nationally, with opponents averaging 190.3 passing yards and a completion percentage of 60.4%. Overall, the Boilermakers are conceding 315.3 yards per game, placing them 54th in the country. They have allowed 1 passing touchdown in addition to 3 rushing touchdowns.

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The Fighting Irish head into this contest with a record of 0-1, having lost their previous game to the Texas A&M Aggies in a narrow 41-40 finish. In that game, Notre Dame allowed 32 rush attempts for 128 yards (4.0 yards per carry). Their passing defense had a challenging outing, permitting a completion rate of 45.9% and giving up 360 yards on 17 of 37 passing attempts. The Fighting Irish totaled 429 yards, executing 71 plays for an average of 6.0 yards per play. Notre Dame’s rushing attack averaged 3.5 yards per carry, ending the game with 136 yards on 39 attempts.

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On the scoring front, the Fighting Irish are positioned 61st nationally, averaging 32.0 points per game. They rack up 371.5 total yards per game, which places them 81st in Division 1. The Notre Dame offense has incurred 46 yards from 10 penalties, ranking 124th in D-1 in terms of self-inflicted wounds. They have thrown 2 interceptions and allowed 1 fumble recovery while securing 41 first downs. This season, the Fighting Irish have passed for a total of 514 yards, averaging 257.0 passing yards per game, which ranks 45th in the nation. On the ground, they are averaging 114.5 yards per game, totaling 229 rushing yards thus far.

Defensively, Notre Dame has given up 262 rushing yards (131.0 yards/game) and allowed 4 rushing touchdowns this season. In the passing game, they have conceded 4 touchdowns and 282.5 yards per game, placing them 126th in Division 1. Overall, the Fighting Irish have surrendered 68 points so far. They have not registered any fumbles but have recorded 1 interception over the season. The defense has participated in 137 plays, ranking them 17th in college football, but are allowing 34.0 points per game, which positions them 119th in D-1.

Who will emerge victorious in this compelling college football matchup between the Boilermakers and Fighting Irish?

Josh’s Recommendation: Bet on the Fighting Irish -27.0

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