Los Angeles Angels vs Milwaukee Brewers Prediction for 9/17/2025: MLB Picks, Best Bets & Odds

Home » Los Angeles Angels vs Milwaukee Brewers Prediction for 9/17/2025: MLB Picks, Best Bets & Odds

Matchup: Los Angeles Angels vs. Milwaukee Brewers

Scheduled Date: Wednesday, September 17, 2025

Venue: American Family Field, Milwaukee, WI

Broadcast: FanDuel Sports Network Wisconsin

Betting Odds: Los Angeles (+220) Milwaukee (-275)

American Family Field is the battleground where the Milwaukee Brewers (91-59) will face off against the Los Angeles Angels (69-81) this Wednesday. The Angels enter the game at +220, while the Brewers are favored at -275. The total runs over/under is set at 8, with expected starting pitchers Jose Soriano and Brandon Woodruff.

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The Angels boast a slugging percentage of .399, with 1,496 strikeouts and 459 walks drawn this season. They have generated 617 RBIs alongside 1,137 hits, giving them a team batting average of .228. As a unit, the Angels have recorded 202 doubles and hit 207 home runs, accumulating 639 runs while presenting a .302 on-base percentage. This season, they average 4.3 runs per game, ranking 23rd in the league.

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The Angels have registered a team ERA of 4.83, placing them 28th in the league, with their pitchers striking out 1,186 batters. This season, Angels pitchers have allowed 209 home runs and 770 total runs (28th in MLB). Their staff has issued 578 walks, currently showing a FIP of 4.82. With 1,330 hits allowed (9.0 per 9 innings), they have given up 713 earned runs and maintain a strikeout to walk ratio of 2.05 along with a collective WHIP of 1.44.

Los Angeles’ bullpen has a save percentage of 51.5%, having entered 149 save situations. Relief pitchers have inherited 204 runners, of which 36.8% have scored. The Angels’ bullpen has pitched in relief 519 times this season, achieving 78 holds (21st in MLB) with 35 saves from 68 opportunities, while blowing 33 saves.

The Kansas City Royals have contributed 3,985 putouts along with 1,311 assists and 90 errors this season. With a .983 fielding percentage, they rank 26th in professional baseball, and have achieved 151 double plays. The Angels have successfully converted 68.8% of batted balls into outs over 11,955 innings, currently sitting at 24th in the league.

Starting pitcher Soriano (career record of 17-20) holds a FIP of 3.77, having faced 1,370 major league hitters. He has allowed 280 hits (7.8 hits per nine innings) with 144 walks. Soriano’s earned run average is 3.83, having permitted 137 earned runs, alongside a WHIP of 1.316 over 322 innings with 305 strikeouts in his career.

On the other side, Milwaukee has tallied 160 home runs and 707 RBIs this season, recording 243 doubles. They have been walked 516 times and scored a total of 762 runs, achieving an on-base percentage of .333 with a team batting average of .260. With a slugging percentage of .408, the Brewers score an impressive 5.08 runs per game, ranking 3rd in MLB. They have been struck out 1,170 times (26th in the league) and amassed 1,330 hits.

The Brewers have achieved a WHIP of 1.236 and a FIP of 3.93. They rank 3rd in the MLB for least hits allowed, giving up only 1,151. Milwaukee’s pitching staff has allowed 589 runs with a sharp 3.63 ERA. Their K/BB ratio stands at 8.90, with 1,317 strikeouts against 498 walks. They have conceded 154 home runs while allowing 3.97 runs every 9 innings (3rd in the league).

In 165 save situations, the Brewers have secured 100 holds and recorded 19 blown saves. Their bullpen has entered 61 save opportunities, clinching 42 saves. They have fielded relievers in 170 high-leverage scenarios, and 133 times with inherited runners. Milwaukee’s inherited scoring percentage is 30.5% among 197 inherited runners, and they sit 5th in the league with a save rate of 68.9%, having sent 507 relief pitchers to the mound this year.

With a fielding percentage of .987 (9th in the majors), the Milwaukee Brewers have tallied 111 double plays, 1,202 assists, and 68 errors. Within their 12,012 innings, their defensive efficiency stands at 70.8%, ranking them 6th in professional baseball.

Woodruff (career record of 52-28) boasts a 3.12 earned run average, having allowed 7.0 hits per nine innings. His impressive strikeout to walk ratio is 4.54, having faced 2,966 opponents in his career. He has allowed 256 earned runs with a WHIP of 1.039 and a FIP of 3.1, accumulating 578 hits allowed and 862 strikeouts in 739 innings pitched.

Which team will come out on top in tonight’s MLB matchup against the spread or on the moneyline?

Guy Bruhn’s Prediction: Back Milwaukee (-275)

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