Predictions for Chicago White Sox vs. Washington Nationals, 9/27/2025 MLB Picks, Best Bets & Odds

• Matchup: Chicago White Sox vs. Washington Nationals
• Date: Saturday, September 27, 2025
• Venue: Nationals Park, Washington, D.C.
• Broadcast: MASN
• Betting Odds: Chicago (+132) Washington (-160)

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This Saturday, Nationals Park will be where the Washington Nationals (65-94) face off against the Chicago White Sox (58-100). The game presents Chicago with odds of +132, while Washington holds -160. The total runs over/under is set at 8.5. Scheduled starting pitchers are Sean Burke for Chicago and Jake Irvin for Washington.

As a team, the Chicago White Sox are producing an average of 3.9 runs per game, ranking them 28th in Major League Baseball. They’ve accumulated a total of 621 runs this season with an on-base percentage of .301. The White Sox have recorded 236 doubles and hit 157 home runs, leading to 600 RBIs and 1,213 hits across the season, with a batting average of .232. Their slugging percentage stands at .371 with 1,326 strikeouts and 490 walks.

The White Sox hold a team-earned run average of 4.25, positioning them 21st in baseball. Their pitching staff has recorded 1,242 strikeouts while allowing 180 home runs and 722 runs, also ranking 21st in the league. They’ve issued 583 walks and carry a FIP of 4.46 for the season. This year, Chicago has allowed 1,305 hits, averaging 8.5 per 9 innings, while conceding 652 earned runs. Their strikeout-to-walk ratio is 2.13, and the team’s WHIP is 1.37.

White Sox relievers have achieved a save percentage of 52.2% in 117 save opportunities. They’ve allowed 31.3% of 233 inherited base runners to score. Chicago pitchers have been utilized with runners on base 159 times and appeared 150 times in high-pressure situations, summoning a total of 517 relief pitchers this season. With 69 holds this year, they rank 28th in the league, tallying 24 saves against 22 blown opportunities.

The Chicago White Sox have totaled 4,146 putouts, alongside 1,244 assists and 98 errors this season. Their fielding percentage stands at .982, ranking them 28th in the majors, along with 128 double plays turned, translating to a 69.6% efficiency in converting balls in play into outs over 12,438 innings, placing them 19th in Major League Baseball.

Sean Burke, with a career record of 6-11, has a FIP of 3.87. He has faced 654 batters, allowing 141 hits (averaging 8.5 hits per nine innings) and has issued 69 walks. His career earned run average is 3.93, having allowed 65 earned runs, with a WHIP of 1.409. Burke has pitched 149 innings, recording 145 strikeouts throughout his career.

The Washington Nationals have achieved a .305 on-base percentage and a .242 batting average this season. Their strikeouts total 1,315 (ranked 16th) along with 1,290 hits. With 152 home runs, they’ve also notched 642 RBIs. The Nationals recorded a team slugging percentage of .387, averaging 4.23 runs per game (20th in MLB). They have hit 256 doubles, drawn 438 walks, and have scored 672 runs overall.

This season, the Nationals’ pitching staff boasts a WHIP of 1.446 and a FIP of 4.71. Their strikeout-to-walk ratio stands at 7.90 (with 1,218 strikeouts and 560 walks), ranking them 29th in total hits allowed, permitting 1,459 hits. They have given up 207 home runs and allow 5.65 runs per 9 innings, ranking 29th. The pitching staff has surrendered a total of 876 runs, resulting in a team ERA of 5.34 (with 828 earned runs allowed).

Washington’s relievers have an inherited scoring rate of 39.5% from 271 inherited base runners. Their bullpen has made appearances 131 times in high-stakes situations and 163 times with runners on base. In 130 save situations, the Nationals have achieved 74 holds but recorded 19 blown saves. They rank 9th in the league with a 65.5% save percentage and employed 569 relief pitchers this year. Throughout this season, Washington has faced 55 save opportunities, successfully claiming 36 saves.

This season, the Washington Nationals have completed 130 double plays and have a fielding percentage of .984 (23rd in the league). They have accumulated 1,376 assists, 90 errors, and 4,189 putouts. In 12,567 innings, their defensive efficiency stands at 68.0% (29th in professional baseball).

Throughout his career, Jake Irvin has allowed 480 hits while earning 373 strikeouts across 482 innings pitched. Irvin has given up 264 earned runs, with a WHIP of 1.342 and a FIP of 4.9. His strikeout-to-walk ratio is 2.23, facing 2,062 batters. Holding a career record of 22-34, Irvin’s ERA is 4.93, with an average of 9.0 hits allowed per nine innings.

Who will prevail in tonight’s MLB matchup against the spread or on the moneyline?

Prediction: Take Chicago (+132)