- Matchup: Miami Dolphins vs San Francisco 49ers
- Date: Sunday, September 20, 2026
- Venue: Levi’s Stadium, Santa Clara, CA
- Broadcast: FOX
- Betting Odds: 49ers favored by 13.5 points
- Total Points Over/Under: 45.5
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The Miami Dolphins (0-1) are set to face off against the San Francisco 49ers (1-0) at Levi’s Stadium this Sunday. The Dolphins are entering the game as 13.5-point underdogs according to bookmakers, with a total points line of 45.5.
Currently at 0-1 this season, the Dolphins suffered a defeat in their last outing against the Las Vegas Raiders, falling 27-13. Quarterback Malik Willis completed 15 of 27 passes for 220 yards, achieving a QB rating of 66.9 and throwing one interception. Running back De’Von Achane led the ground game with 36 yards on 11 carries (3.3 yards per carry). Receiver Caleb Douglas had a standout performance with 94 yards on five receptions, averaging 18.8 yards per catch. Overall, the Dolphins rushed the ball 18 times for a total of 74 yards, averaging 4.1 yards per attempt. They managed 45 plays for a combined total of 259 yards. Defensively, Miami allowed 21 completions out of 30 attempts for 160 yards with a completion rate of 70.0%. On the ground, they conceded 130 yards on 37 carries, averaging 3.5 yards allowed per rush.
This season, the Dolphins have accumulated a total of 259 offensive yards. They have recorded 7 first downs and incurred 8 penalties for 61 yards. In terms of scoring, Miami has achieved just one rushing touchdown, alongside two turnovers (one interception and one fumble). Their rushing average stands at 74.0 yards, ranking them 27th in the league. They are currently scoring an average of 13.0 points per game.
Defensively, Miami has allowed 160 passing yards, ranking them 6th in the NFL. They permit an average of 160.0 passing yards per game with a 70.0% completion rate. Additionally, they have conceded 130 rushing yards so far this season. Collectively, the Dolphins allow 290.0 total yards per game, placing them 15th in the league, with a defensive average of 27.0 points allowed per game, situating them 18th overall.
The 49ers enter this game with a 1-0 record thus far. In their most recent matchup, the 49ers triumphed over the Los Angeles Rams with a score of 27-7. Running back Kaelon Black carried the ball 14 times for 65 yards, posting an average of 4.6 yards per carry. Mike Evans emerged as the top receiver for San Francisco, catching 6 passes for 49 yards (8.2 yards per catch). Quarterback Brock Purdy threw for 205 yards and 3 touchdowns, completing 25 of 34 attempts, achieving a QB rating of 105.6 while throwing one interception. San Francisco allowed 29 attempts on the ground, giving up 122 yards (4.2 yards per rush). The defense yielded a completion percentage of 60.7%, allowing 168 yards on 17 of 28 passing plays. Overall, the 49ers amassed 379 total yards and executed 64 plays, averaging 5.9 yards per play while rushing for 5.8 yards per attempt with 174 yards on 30 tries.
Regarding scoring efficiency, the 49ers currently rank 14th in the league, recording an average of 27.0 points per game. This season, they have achieved a total of 205 passing yards per game. Their rushing statistics reflect an average of 174.0 yards per outing, with a total offensive average of 379.0 yards, placing them 11th in professional football. The 49ers have committed 2 penalties for just 21 yards, ranking them last in the league for crucial infractions. They have also given up 1 interception and secured 12 first downs.
Defensively, they have not allowed any passing touchdowns, holding opponents to 168.0 passing yards per game, ranking 8th in the league. They have limited their opponents to 122 rushing yards total. The defense has notched 2 takeaways (one fumble and one interception) this year, allowing a mere 7 points. With 57 defensive plays, they rank 13th in the league, maintaining an impressive defensive average of only 7.0 points against per game, placing them 1st in the NFL.
Who will prevail in this highly-anticipated Dolphins-49ers clash against the spread?
Expert’s Prediction: Bet on the 49ers -13.5
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