Arizona Diamondbacks and San Diego Padres Prediction for 9/27/2025: MLB Picks, Best Bets & Odds

Home » Arizona Diamondbacks and San Diego Padres Prediction for 9/27/2025: MLB Picks, Best Bets & Odds
  • Matchup: Arizona Diamondbacks vs San Diego Padres
  • Event Date: Saturday, September 27, 2025
  • Venue: Petco Park, San Diego, CA
  • Broadcast: Padres.TV
  • Betting Odds: Arizona (+132) San Diego (-160)

This page may include affiliate links at no extra cost to you, thanks for your support.

The San Diego Padres (87-72) host the Arizona Diamondbacks (80-78) at Petco Park this Saturday. The moneyline for this matchup stands at +132 for the Diamondbacks and -160 for the Padres, with the over/under set at 9 runs. Pitchers on the mound will be Eduardo Rodriguez for Arizona and Michael King for San Diego.

MLB picks Ketel Marte Arizona Diamondbacks predictions best bets odds

Arizona boasts a slugging percentage of .434 and has struck out 1,271 times while accumulating 527 walks. The team has recorded 761 RBIs alongside 1,348 hits, maintaining a batting average of .252. The Diamondbacks have also hit 271 doubles and 210 home runs this season, scoring 782 runs with an on-base percentage of .325. Averaging 5.0 runs per game, they rank 4th in Major League Baseball.

Arizona’s pitching staff has a K/BB ratio of 2.59 and a WHIP of 1.31. They have conceded 187 home runs and allowed 753 runs throughout the season (23rd in the league). The Diamondbacks have given up 1,362 hits (8.7 per 9 innings) and 693 earned runs, resulting in a team ERA of 4.42 (23rd in MLB). Collectively, they have struck out 1,254 batters while allowing 485 walks, and their FIP stands at 4.24 for the season.

This year, Arizona’s bullpen has featured 489 pitchers, inheriting 192 base runners, with 33.3% of those runners scoring. They have tallied 42 saves from 71 opportunities, yielding a save rate of 59.2% from 164 save situations. The Diamondbacks’ relief pitchers have accumulated 88 holds this season (14th in the league) and have made 146 high-leverage appearances.

On defense, the Diamondbacks have recorded 4,233 putouts, 1,412 assists, and 80 errors. With a fielding percentage of .986, they rank 16th in baseball and have executed 125 double plays. The team has converted 69.6% of balls in play into outs over 12,699 innings, placing them 20th in the league.

Eduardo Rodriguez has logged 1,298 innings, amassing 1,291 strikeouts in his career. With a career record of 94-65, Rodriguez boasts a FIP of 4.11 and has faced 5,554 opposing batters. His ERA stands at 4.17 (602 earned runs), while he has a WHIP of 1.331, permitting 1,274 hits (8.8 hits per 9 innings) along with 454 walks.

San Diego has hit 147 home runs this season, driving in 639 runs. With 248 doubles and 499 walks, they have scored 678 runs. The Padres have a team OBP of .320 and a batting average of .252 this year, accompanied by a SLG of .388 and averaging 4.26 runs per game (19th in MLB). They have struck out 1,137 times (28th in the league), tallying 1,339 hits.

The Padres’ pitching staff holds a WHIP of 1.203 and a FIP of 4.01. Their K/BB ratio is an impressive 8.90 (1,392 strikeouts versus 519 walks), ranking them first for the fewest hits allowed with 1,173. They have given up 174 homers and average just 3.92 runs per 9 innings (2nd in the league). As a unit, the San Diego pitching staff has allowed 612 runs for the season, posting an ERA of 3.64 (569 earned runs).

With 172 save situations this season, San Diego has recorded 103 holds and 16 blown saves. Their bullpen has been called into action during 64 save opportunities, converting 48 of those into saves. Across 208 high-leverage appearances, they’ve had 181 situations with runners on. Their inherited scoring rate is 29.4% from 255 inherited runners, ranking 1st in baseball with a save percentage of 75.0%, having deployed 564 relief pitchers this year.

Over 12,654 innings, the Padres show a defensive efficiency of 71.8% (3rd in professional baseball). The team has turned 114 double plays, achieving a fielding percentage of .987 (10th in professional baseball), while recording 1,208 assists, 73 errors, and 4,218 putouts throughout the season.

Michael King has allowed 417 base hits with 556 strikeouts over 491 innings pitched in his career. With a career win-loss record of 31-29, he has an impressive 3.26 ERA and allows 7.6 hits per nine innings. He has surrendered a total of 178 earned runs while boasting a WHIP of 1.195 and a FIP of 3.2. His K/BB ratio stands at 3.27 after facing 2,057 batters during his career.

Who will come out on top in tonight’s MLB game against the spread or moneyline?

Prediction: Back San Diego (-160)

Some links on this page are affiliate links. If you sign up or make a purchase through them, we may earn a small commission always at no extra cost to you. Thanks for helping us keep this site running.

Pick: San Diego Padres (-160)
Bet Now

Leave a Reply

Your email address will not be published. Required fields are marked *

New Bookmakers
Bet99

Proud Partner of the NHL + Excellent live betting

 

Betway

Widest Range of Betting Options + Robust in-play with streaming

BetMGM

Top-Rated Betting App in Ontario with Live streaming & Cash-out

Sports Interaction

Crafted for Canada’s Bettors. Best Odds For NHL, CFL & NFL

© 2025 BettingEdge.ca. All Rights Reserved. BettingEdge.ca is your trusted source for Canadian sportsbook reviews, betting tips, and responsible gaming resources. Must be 19+ to bet. Play responsibly.