Arizona Cardinals vs Los Angeles Chargers Outlook, 9/13/2026 NFL Picks, Top Bets & Odds Week 1

Home » Arizona Cardinals vs Los Angeles Chargers Outlook, 9/13/2026 NFL Picks, Top Bets & Odds Week 1

  • Matchup: Arizona Cardinals vs Los Angeles Chargers
  • Game Date: Sunday, September 13, 2026
  • Venue: SoFi Stadium, Inglewood, CA
  • Broadcast: CBS
  • Betting Odds: Chargers -10.5
  • Over/Under Total: 46.5

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The Los Angeles Chargers, who finished last season with an 11-6 record, will take on the Arizona Cardinals, who ended their last campaign at 3-14, this Sunday at SoFi Stadium. The Cardinals are set as 10.5-point underdogs, with a total point line of 46.5.

Last season, the Arizona Cardinals wrapped up with a challenging 3-14 record. In their final clash, they suffered a defeat against the Los Angeles Rams, concluding with a score of 37-20. Quarterback Jacoby Brissett completed 22 of 31 passes for 243 yards and 2 touchdowns, achieving a QB rating of 101.9, though he did toss one interception. Michael Wilson excelled with an average of 19.8 yards per reception, totaling 99 yards on 5 receptions. Emari Demercado led the rushing attack with 29 yards on 2 carries, averaging an impressive 14.5 yards per attempt. Overall, the Cardinals executed 47 offensive plays, racking up a total of 317 yards, with 15 rush attempts contributing 79 yards at 5.3 yards per carry. Defensively, they struggled, giving up 143 rushing yards on 31 carries (4.6 yards per carry) and allowing the Rams to complete 25 of 40 passes for a total of 252 yards, resulting in a 62.5% completion rate.

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In terms of scoring, the Cardinals averaged 20.9 points per game, while their rushing attack produced just 93.1 yards per game, placing them 31st in the league. They accumulated a total of 5,538 yards last season, achieving 216 first downs while being penalized 115 times for 842 yards. The offense turned the ball over 21 times (11 interceptions and 10 fumbles), garnering 29 passing touchdowns and another 9 rushing touchdowns.

On the defensive side, the Cardinals allowed a staggering 3,923 passing yards, ranking 24th in the league. They permitted an average of 230.8 passing yards per game with a completion percentage against of 65.6%. Additionally, they ceded 2,158 rushing yards throughout the season, giving up 31 passing and 19 rushing touchdowns. Overall, their average of 357.7 yards allowed per game positioned them at 27th in professional football. They allowed an average of 4.4 yards per rush and 126.9 rushing yards per game, ranking 29th in terms of points given up, allowing opponents to score 28.7 PPG.

On the other hand, the Chargers completed their previous season at 11-6. In their last game, they faced the New England Patriots but fell short with a final score of 16-3. Justin Herbert ran the ball 10 times, gaining 57 yards and averaging 5.7 yards per attempt. Ladd McConkey was a notable target, catching 3 passes for 32 yards (10.7 yards per reception). Herbert’s performance consisted of 159 yards on 19 completions out of 31 attempts, achieving a QB rating of 74.5 without throwing any interceptions, with an average of 5.1 yards per pass. The Chargers’ defensive unit allowed 29 rushing attempts for 146 yards (5.0 yards per rush), while their pass defense conceded a completion percentage of 56.7%, yielding 235 yards on 17 completions out of 30 attempts. Overall, Los Angeles managed 207 offensive yards through 53 plays, averaging 3.9 yards per play, and had 87 rushing yards on 22 attempts at an average of 4.0 yards per carry.

In terms of scoring capabilities, the Chargers ranked 20th in the league, averaging 21.6 points per game. They threw for a total of 3,608 yards last season, holding an average of 212.2 passing yards per game, which ranked 18th overall. Their rushing offense recorded an average of 121.6 yards per game with a total accumulation of 2,067 yards. Overall, the Chargers averaged 333.8 yards per game, ranking 12th in professional football. Their offense faced 104 penalties for a cumulative total of 787 yards, placing them 21st in the league regarding helping the opposition. They surrendered 14 interceptions and 7 fumbles, achieving 185 first downs during the season.

Defensively, the Chargers allowed 20.0 points per game, ranking them 9th in the league. Their pass defense permitted 16 touchdowns along with an average of 179.9 passing yards per game, ranking 5th in the league. The Chargers yielded a total of 1,791 rushing yards, averaging 105.4 yards per game, with 16 rushing touchdowns allowed last season. The defense was on the field for a total of 966 plays from the line of scrimmage, ranking them 2nd overall. They recorded 23 takeaways, which included 4 forced fumbles and 19 interceptions, allowing a total of 340 points throughout the season.

Who will emerge victorious in the Cardinals vs. Chargers matchup against the spread this Sunday?

Prediction: Take the Chargers -10.5

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Pick: Los Angeles Chargers -10.5
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