- Matchup: Arizona Cardinals vs San Francisco 49ers
- Event Date: Sunday, September 27, 2026
- Venue: Levi’s Stadium, Santa Clara, CA
- Broadcast: FOX
- Betting Odds: Cardinals +8.5
- Total Points (Over/Under): 47
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The Arizona Cardinals (1-1) are set to travel to Levi’s Stadium this Sunday, aiming to secure a victory against the unbeaten San Francisco 49ers (2-0). Opening odds favor the 49ers by 8.5 points as per Las Vegas bookmakers, with a total points line set at 47.
With a 1-1 record this season, the Arizona Cardinals are looking to rebound after a recent loss to the Seattle Seahawks, where they fell 31-7. Quarterback Jacoby Brissett completed 17 out of 28 passes for 95 yards and managed 1 touchdown, while finishing the game with a quarterback rating of 63.8 and one interception. Running back Jeremiyah Love led the ground game with 9 carries for 29 yards, averaging 3.2 yards per carry. Tight end Trey McBride had a productive outing, catching 8 passes for 41 yards, averaging 5.1 yards per reception. The Cardinals attempted 17 rushes, accumulating 70 yards for an average of 4.1 yards per carry. Overall, the team ran a total of 45 plays for 151 yards. Defensively, Arizona allowed 19 completions on 26 attempts for 219 passing yards, yielding a completion percentage of 73.1%. Against the rush, they permitted 162 yards on 40 carries, averaging 4.1 yards per carry allowed.
In terms of scoring, the Arizona Cardinals are averaging 16.5 points per game. Their rushing attack is averaging 93.0 yards, placing them 24th in the league. Over the season, they have amassed 544 total yards, achieved 19 first downs, but have been penalized 14 times for a total of 159 yards. Additionally, they have committed 1 turnover and scored 2 touchdowns through the air along with 1 rushing touchdown.
Defensively, the Cardinals have given up 406 passing yards, ranking them 14th in the NFL, allowing 203.0 yards per game via the pass with a completion rate of 67.9%. They have conceded a total of 243 rushing yards over the two games, letting in 4 passing touchdowns and 2 rushing touchdowns. Overall, they rank 14th in the league in total defense, allowing an average of 22.5 points per game.
The San Francisco 49ers enter this matchup with a perfect record of 2-0. In their previous game, they dominated the Miami Dolphins, winning 35-13. Quarterback Brock Purdy showcased impressive performance, rushing 3 times for 30 yards with an average of 10.0 yards per attempt. Star tight end George Kittle was a key contributor, catching 4 passes for 80 yards, averaging a whopping 20.0 yards per reception. Purdy completed 20 of 22 passes for 287 yards and 2 touchdowns, garnering a remarkable quarterback rating of 149.1 without throwing any interceptions. The 49ers allowed 29 rushing attempts resulting in 102 yards, averaging 3.5 yards per rush. Defensively, they permitted a completion rate of 60.9%, yielding 182 yards on 14 of 23 passing. San Francisco finished with 382 total yards while executing 49 plays, averaging 7.8 yards per play.
Averaging 380.5 total yards per game, the San Francisco 49ers rank 8th in the league. They manage 134.5 rushing yards each game, totaling 269 rushing yards so far this season. With 28 first downs, they are solid offensively but have accumulated 99 yards in 9 penalties, ranking 28th for penalties in the league. Passing-wise, the 49ers have thrown for 492 yards, averaging 246.0 yards per game, which places them in the top 10. Currently, they rank 5th in points scored, averaging 31.0 points per game.
Defensively, they have allowed only 1 touchdown through the air and 175.0 passing yards per game, which ranks them 9th in the league. They’ve given up a total of 224 rushing yards, averaging 112.0 yards per game on the ground, along with 1 rushing touchdown this season. The 49ers’ defense has forced 2 turnovers (1 fumble and 1 interception) and has allowed just 20 points overall, ranking them 3rd in the NFL in points allowed per game at 10.0.
Who will emerge victorious in this Cardinals vs. 49ers clash this Sunday?
Expert’s Pick: Go with the Cardinals +8.5
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