Chicago Cubs vs. Cincinnati Reds Analysis, 9/20/2026 MLB Picks, Top Bets & Odds

Home » Chicago Cubs vs. Cincinnati Reds Analysis, 9/20/2026 MLB Picks, Top Bets & Odds

  • Matchup: Chicago Cubs vs Cincinnati Reds
  • Scheduled Date: Sunday, September 20, 2026
  • Venue: Great American Ball Park, Cincinnati, OH
  • Broadcast: Reds.TV
  • Betting Odds: Chicago (-122), Cincinnati (+102)

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The Cincinnati Reds (71-82) are set to challenge the Chicago Cubs (85-68) at Great American Ball Park this Sunday. The Cubs are favored at -122, while the Reds are listed at +102. The over/under for this matchup stands at 8. The starting pitchers for this contest will be David Peterson and Rhett Lowder.

MLB betting insights for Cubs vs Reds

Offensively, the Chicago Cubs lead the league with an impressive average of 5.3 runs per game. They have amassed a total of 817 runs with a collective on-base percentage of .340. The team has recorded 261 doubles and 211 home runs while tallying 772 RBIs and 1,320 hits throughout the season, boasting a batting average of .252. Additionally, the Cubs maintain a slugging percentage of .431, having struck out 1,271 times and drawn 643 walks.

Chicago’s pitchers have a strikeout-to-walk ratio of 2.52 and a collective WHIP of 1.27. This season, they’ve permitted 227 home runs and a total of 674 runs, ranking 13th in the league. They’ve allowed 1,263 hits (8.3 per 9 innings), resulting in an ERA of 4.19, which sits at 17th in MLB. The staff has struck out 1,188 batters while issuing 471 walks, with a FIP of 4.68 this year.

Cubs relievers have entered games with opponents on base 155 times and have made 146 high-leverage appearances. This unit has recorded 52 holds so far (30th in MLB) and has a save rate of 55.0% with 119 save opportunities. Their performance has led to 33 saves on the season, with 27 blown saves from 60 chances. Cubs relievers have inherited 217 base runners this year, with 33.2% crossing home plate. For the season, Chicago has utilized 489 relievers.

Defensively, the Cubs convert 71.8% of balls in play into outs, placing them 3rd in the league. Chicago has logged 4,098 putouts, 1,448 assists, and 56 errors this season, maintaining a fielding accuracy of .990—the best in professional baseball—with 116 double plays executed.

David Peterson has pitched 691 innings in his MLB career, accumulating 675 strikeouts and holding a career record of 42-32. He has a FIP of 4.07 and has faced 2,974 batters, with an ERA of 4.13 (317 earned runs). His WHIP stands at 1.383, having allowed 662 hits (8.6 per nine innings) and issued 294 walks.

In contrast, the Cincinnati Reds hold a team on-base percentage of .307 and a batting average of .230 this season. They’ve struck out an MLB-leading 1,458 times, accumulating 1,168 hits. Cincinnati has logged 203 home runs and 605 RBIs, with a slugging percentage of .396. They score 4.14 runs per game, ranking 26th in the league, while hitting 212 doubles and drawing 534 walks for a total of 633 runs scored.

The Reds’ pitching staff has surrendered 787 runs this year, resulting in a team ERA of 4.87 (733 earned runs). They’ve given up 203 home runs, averaging 5.23 runs allowed per 9 innings (28th in MLB). Cincinnati has a WHIP of 1.450 and a FIP of 4.81 this season, with a strikeout-to-walk ratio of 8.20 (1,233 strikeouts to 638 walks). They currently rank 26th in total hits allowed with 1,325.

The Reds’ relief pitchers have inherited 240 base runners this season, with a scoring rate of 27.1%. They’ve entered 180 high-leverage situations and 160 times with runners on base. Across 149 save opportunities, the Reds have recorded 83 holds and 22 blown saves, maintaining a 64.5% save percentage, ranking 14th in MLB, with 545 relievers used this season.

Cincinnati has played 12,186 innings, achieving a defensive efficiency of 69.4% (20th in professional baseball). The Reds have completed 108 double plays, with a fielding percentage of .984 (20th in MLB)—accumulating 1,227 assists, 87 errors, and 4,062 putouts this year.

Rhett Lowder, in his professional career, has given up 163 hits and notched 120 strikeouts over 154 innings. He holds an 8-13 record with a 4.90 ERA, allowing 9.5 hits per nine innings. With 84 earned runs to his name, his WHIP stands at 1.478 and his FIP at 4.8. He boasts a strikeout-to-walk ratio of 1.85, having faced 691 hitters in his career.

Which team will secure the victory against the spread or for the moneyline tonight?

Selection: Choose Cincinnati (+102)

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Pick: Cincinnati Reds (+102)
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