- Matchup: Cleveland Guardians vs Boston Red Sox
- Date: Wednesday, September 23, 2026
- Venue: Fenway Park, Boston, MA
- Broadcast: NESN
- Betting Odds: Cleveland (+125) Boston (-150)
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On Wednesday, Fenway Park will host an exciting game where the Boston Red Sox (84-72) aim to outplay the Cleveland Guardians (81-75). Current betting odds indicate the Guardians at +125, while the Red Sox are at -150. The total runs set for the game is 8, with pitching assignments for Foster Griffin and Sonny Gray.

The Cleveland Guardians are averaging 4.2 runs per game, ranking them 26th in the league. They have scored a total of 649 runs with a team on-base percentage of .315. Cleveland has recorded 241 doubles and 152 home runs this season, also achieving 622 RBIs and 1,238 hits, resulting in a batting average of .238. The team has a slugging percentage of .377, with 1,233 strikeouts and 548 walks this year.
Cleveland’s pitching staff maintains an earned run average (ERA) of 3.78 this season (8th in the league) and has struck out 1,476 batters. They have conceded 169 home runs and 647 runs, also ranking 8th in the league. Guardians pitchers have issued 513 walks, resulting in a FIP of 3.82 for the season. Cleveland’s hurlers have allowed 1,232 hits (8.0 per 9 innings) and recorded 582 earned runs, showcasing a strikeout-to-walk ratio of 2.88 and a team WHIP of 1.26.
The Guardians’ relievers have achieved a save percentage of 73.3%, entering 170 save scenarios with a total of 44 saves, though they have blown 16 of their 60 save opportunities. Inherited runners for the relief squad number 257, with 28.4% successfully scoring. The bullpen has stepped onto the mound 532 times this season, achieving 108 holds, ranking 2nd in the league.
Defensively, Cleveland has converted 69.3% of batted balls into outs over 12,471 innings, positioning them at 22nd in MLB. The Guardians have accumulated 4,157 putouts, 1,213 assists, and 81 errors, resulting in a fielding percentage of .985, placing them 17th in baseball, and they have successfully executed 101 double plays.
Griffin, with a 4-2 career record, has a FIP of 5.90 after facing 207 major league hitters. He has allowed 52 hits (10.4 hits per 9 innings) and issued 20 walks. With an ERA of 5.99 (30 earned runs), Griffin has pitched for 45 innings, accumulating 40 strikeouts.
The Boston Red Sox have belted 161 home runs this season, alongside 648 RBIs. They have accumulated 277 doubles, walked 497 times, and scored 678 runs overall. The Red Sox feature a team on-base percentage of .320 and a batting average of .246, with a slugging percentage of .401 and an average of 4.35 runs per game (20th in MLB). They have registered 1,271 strikeouts (20th in the league) and 1,286 hits.
As for their pitching, the Red Sox have allowed 598 runs this season, boasting a combined ERA of 3.59 (553 earned runs). Their pitchers have given up 150 home runs and permit 3.88 runs per 9 innings (4th in MLB), holding a team WHIP of 1.235 and a FIP of 3.67. Their strikeout-to-walk ratio stands at 8.80, with 1,352 strikeouts and 453 walks, positioning them 14th in MLB for hits allowed (1,259).
Bostons relievers rank 2nd in the league with a 75.9% save percentage, having sent 472 bullpen pitchers into action this season. They’ve entered high leverage situations 142 times and allowed runners on base 121 times. With 152 save opportunities, the Boston bullpen has 92 holds and recorded 14 blown saves, converting 44 of 58 save chances.
In 12,474 innings, Boston has an efficiency rating of 69.4% in defense (21st in the league). The Red Sox have completed 118 double plays with a fielding percentage of .986 (15th in baseball), along with 1,361 assists, 79 errors, and 4,158 putouts this year.
Gray holds a career record of 142-107 with a 3.52 ERA, averaging 7.9 hits per 9 innings. He boasts a K/BB ratio of 3.11 after facing 8,613 opposing hitters. He has yielded 814 earned runs, maintaining a WHIP of 1.194 and a FIP of 3.5. Throughout his MLB career, Gray has allowed 1,819 hits while compiling 2,071 strikeouts over 2,081 innings.
Who will take home the victory in tonight’s MLB game against the spread or moneyline?
Prediction: Support Cleveland (+125)
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