- Matchup: Detroit Lions vs Buffalo Bills
- Date: Thursday, September 17, 2026
- Venue: Highmark Stadium, Orchard Park, NY
- Broadcast: Prime Video
- Point Spread: Lions +4.5
- Over/Under Total: 53
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The Detroit Lions (1-0) are gearing up for an exciting matchup against the Buffalo Bills (1-0) at Highmark Stadium this Thursday. The Bills have been designated as 4.5-point favorites by the oddsmakers, with an over-under set at 53.
Starting the season with a 1-0 record, the Lions recently secured a nail-biting 31-30 victory over the New Orleans Saints. Jahmyr Gibbs spearheaded the Lions’ rushing attack with an impressive 156 yards on 29 carries (5.4 yards per attempt). Amon-Ra St. Brown contributed significantly in the air, registering 67 yards on 10 receptions for an average of 6.7 yards per catch. Quarterback Jared Goff completed 26 of 39 passes for 206 yards, tossing 2 touchdowns and maintaining a QB rating of 96.7 without any interceptions. While the defense allowed 91 rushing yards on 25 attempts (3.6 yards per carry), they also gave up 378 passing yards, resulting in a 62.5% completion rate. The team executed 72 plays for a total of 369 yards, while the ground game amassed 165 yards on 33 carries, averaging 5.0 yards per attempt.
When it comes to scoring, the Lions are averaging 31.0 points per game and rank 5th in the league for rushing yards, with an average of 165.0. They have accumulated a total of 369 yards this season and achieved 10 first downs offensively. However, they recorded 8 penalties for a total of 61 yards and have turned the ball over once. In terms of touchdowns, Detroit has found the end zone 2 times through the air and 2 times on the ground.
Defensively, the Lions have allowed 378 passing yards, ranking them 32nd in the league, with an average of 378.0 yards conceded per game and a completion rate of 62.5%. On the ground, they’ve permitted 91 rushing yards over one game, giving up 3 touchdowns through the air and 1 on the ground. Altogether, they rank 29th in the league, allowing 469.0 total yards per game and 30.0 points per game, placing them at 22nd in defensive scoring.
The Buffalo Bills enter this encounter with a current record of 1-0. They enjoyed a thrilling 36-31 victory over the Houston Texans in their last game. Josh Allen threw for 334 yards on 20-29 passing, accounting for 2 touchdowns and achieving a 130.5 QB rating, while keeping the ball secure with no interceptions and an average of 11.5 yards per throw. Running back James Cook carried the ball 13 times for 57 yards, averaging 4.4 yards per carry. Dalton Kincaid was Allen’s favorite target, catching 5 passes for a remarkable 130 yards (26.0 yards per reception). The Bills averaged 4.1 yards on the ground, totaling 86 yards on 21 carries, and amassed 409 yards throughout the game on 50 plays (8.2 yards per play). The Buffalo passing defense held opponents to a completion percentage of 68.4%, allowing 257 yards on 26 completions out of 38 attempts, and conceded 124 yards on 32 rushing attempts (3.9 yards per carry).
In terms of statistics, the Bills lead the league by averaging 409.0 yards per game and rank 6th in total offense. Their rushing attack has produced an average of 86.0 yards per game, resulting in 13 first downs. Offensively, the Bills have committed 10 fouls, yielding a total of 85 yards, which places them 6th in the league for penalties. Through two games, they’ve earned 323 passing yards, and in scoring efficiency, they rank 5th with a robust average of 36.0 points per game.
Defensively, the Bills allow an average of 31.0 points, putting them 25th in the NFL. They have given up 2 touchdowns through the air and allow 257.0 passing yards per game (25th overall). Their rushing defense has yielded 124 yards, and their defensive unit has participated in 73 plays, ranking 31st in the league. They have managed to force 2 turnovers this season, as their overall points allowed stands at 31.
Who will triumph in tonight’s Lions vs Bills clash against the spread?
Prediction: Take the Lions +4.5
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