Minnesota Twins and New York Mets Prediction for 4/22/2026: MLB Picks, Best Bets, and Odds

Home » Minnesota Twins and New York Mets Prediction for 4/22/2026: MLB Picks, Best Bets, and Odds

  • Matchup: Minnesota Twins vs New York Mets
  • Date: Wednesday, April 22, 2026
  • Venue: Citi Field, Queens, NY
  • Broadcast: Sportsnet New York
  • Odds/Point Spread: Minnesota (-130) New York (+110)

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The New York Mets (7-15) will host the Minnesota Twins (11-11) this Wednesday at Citi Field. The moneyline for this exciting match shows Minnesota at -130 while New York opens at +110. The total runs over/under is set at 8.5. Starting pitchers for the game are Joe Ryan and Clay Holmes.

MLB Predictions for Minnesota Twins by Josh Bell

The Minnesota Twins have recorded 27 doubles and hit 26 home runs as a team this season. Their slugging percentage stands at .381, and they have struck out 193 times while drawing 98 walks. Averaging 5.1 runs per game, they rank 7th in the league. With a total of 107 RBIs and 166 hits, their batting average is .230. They have scored 112 runs this season with an on-base percentage of .332.

The Twins’ pitching staff boasts a K/BB ratio of 2.35 and has achieved a WHIP of 1.37. They have allowed 13 home runs and 100 runs total (14th in MLB), with 189 base hits surrendered and 88 earned runs. As a unit, Minnesota carries an earned run average of 4.06 (16th in baseball) and has struck out 183 batters, while issuing 78 walks, leading to a FIP of 3.58.

With a 62.5% save rate, the Twins’ bullpen has been active in 25 save situations, achieving 5 saves while blowing 3 out of 8 chances. Inheriting 30 base runners, relief pitchers allowed 23.3% of those to score. The bullpen has encountered players on base 21 times and has made 18 appearances in high-leverage spots, using 73 different pitchers and earning 17 holds (8th in MLB).

The Twins have compiled 585 putouts, 161 assists, and 14 errors this season, resulting in a fielding percentage of .982, which places them 25th in the league. They have turned 18 double plays and converted 67.1% of balls in play into outs from 1,755 innings of play, ranking 27th in MLB.

Joe Ryan, with a career record of 48-38, has faced 2,710 hitters, allowing 552 hits (7.4 per nine innings) and issuing 154 walks. His earned run average is 3.77, allowing 280 earned runs, with a WHIP of 1.057 and 747 strikeouts over 668 innings pitched.

For the New York Mets, the team has hit 16 home runs this year with 68 RBIs, alongside 29 doubles. With 72 runs scored and 64 walks issued, they currently have a team OBP of .288 and a batting average of .226. Their slugging percentage stands at .336 and they average only 3.27 runs per game (30th in MLB). The Mets have struck out 178 times (24th in MLB) and racked up 169 hits.

The Mets` pitching staff holds a WHIP of 1.284 and a team FIP of 3.82, ranking 18th in baseball with 178 hits allowed. They have conceded 97 runs with a 4.06 ERA (89 earned runs), maintaining an impressive strikeout-to-walk ratio of 8.70 (190 strikeouts against 75 walks). New York’s pitchers have allowed 21 home runs, giving up 4.43 runs per 9 innings (12th in the league).

New York’s relievers have a 52.4% inherited score percentage from 21 inherited runners. They have participated in high-pressure situations 27 times and encountered runners on base 20 times. In 12 save situations, they have earned 7 holds and recorded 3 blown saves, holding a 40.0% save rate (28th in MLB). They have sent 64 bullpen pitchers to the mound this season.

The Mets have turned 14 double plays with a .986 fielding percentage (13th in professional baseball). They have registered 202 assists, 11 errors, and 592 putouts throughout the season. With an efficiency of 70.0% in defense over 1,776 innings, they rank 18th in professional baseball.

Clay Holmes, with a career record of 38-32, holds a 3.58 ERA and allows 7.7 hits per 9 innings. He has a strikeout-to-walk ratio of 2.21, opposing 2,261 batters during his career. He’s permitted 209 earned runs, carrying a WHIP of 1.293 and a FIP of 3.5. Over 526 innings pitched, Holmes has yielded 452 hits and accumulated 505 strikeouts.

Who will take home the win in this highly anticipated MLB match—will it be against the spread or the moneyline?

Prediction: Back New York (+110)

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Pick: New York Mets (+110)
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