Ohio State Buckeyes vs. Indiana Hoosiers Matchup Preview, 10/17/2026 College Football Insights, Top Picks & Odds

Home » Ohio State Buckeyes vs. Indiana Hoosiers Matchup Preview, 10/17/2026 College Football Insights, Top Picks & Odds

  • Matchup: Ohio State Buckeyes vs Indiana Hoosiers
  • Event Date: Saturday, October 17, 2026
  • Venue: Memorial Stadium, Bloomington, IN
  • Broadcast: FOX
  • Betting Odds: Hoosiers (+3.5)
  • Over/Under Total: 50.5

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The undefeated Indiana Hoosiers (6-0) will face off against the Ohio State Buckeyes (5-1) at Memorial Stadium on Saturday, October 17, 2026. The Buckeyes are entering this contest as 3.5-point favorites, with the over/under set at 50.5.

This season, the Ohio State Buckeyes have a record of 5-1. In their most recent matchup, they triumphed over the Maryland Terrapins with a commanding score of 45-16. Defensively, the Buckeyes allowed 82 rushing yards on 28 attempts, averaging just 2.9 yards per carry. Through the air, they conceded 12 completions out of 25 attempts for a total of 64 passing yards, resulting in a completion rate of 48%. Overall, Ohio State totaled 69 plays for 449 yards and recorded 207 rushing yards on 48 attempts, averaging 4.3 yards per rush.

College Football Predictions and Best Bets

In terms of scoring, the Ohio State Buckeyes average an impressive 42.7 points per game. They currently rank 60th in the nation with an average of 165.7 rushing yards per game. For the season, they have accumulated a total of 3,021 yards. When assessing their scoring distribution, Ohio State has achieved 20 touchdown passes and 13 rushing touchdowns, while converting 152 first downs. However, they have also suffered from 40 penalties that have cost them 314 yards, alongside 6 turnovers this season.

Ohio State boasts a strong defensive resume, ranking 8th nationally by allowing just 13.2 points per game. They permit opponents to run for an average of 3.2 yards per attempt, totaling 96.2 rushing yards per game across the season, with 577 rushing yards surrendered over 6 games. In terms of passing defense, they rank 23rd, allowing 904 yards and an average of 150.7 yards per game with a completion percentage of 53.0%. Overall, they surrender 246.8 yards per game, placing them 5th in the nation, with 2 passing touchdowns and 5 rushing touchdowns allowed.

The Hoosiers enter this game with a perfect 6-0 mark for the season. In their last outing, they secured a narrow victory over the Nebraska Cornhuskers, finishing 20-17. Defensively, Indiana allowed 39 rushing attempts, yielding 128 yards (3.3 yards per carry). Their pass defense permitted a completion percentage of 56.8%, allowing 264 yards on 25 of 44 passing attempts. Overall, Indiana totaled 328 yards while executing 44 plays, averaging 7.5 yards per play. On the ground, they managed just 65 yards across 22 attempts at an average of 3.0 yards per carry.

The Indiana Hoosiers have an average offensive output of 462.7 yards per game, ranking them 20th in Division I. They have accumulated 173 penalty yards across 20 infractions, ranking 135th in college football for penalties. Averaging 221.3 rushing yards per game, they have rushed for a total of 1,328 yards this season. The Hoosiers have not thrown any interceptions but have fumbled once, accumulating 129 first downs. In scoring, they rank 14th nationally with an average of 40.2 points per game. To date, they have recorded 1,448 passing yards, averaging 241.3 passing yards per game, which places them at 60th in D-1.

Defensively, Indiana has permitted a total of 450 rushing yards (averaging 75.0 yards per game) and allowed 5 rushing touchdowns this season. They have given up 3 passing touchdowns and 188.5 passing yards per game, positioning them 41st in Division I. Overall, they have surrendered just 71 points this season. Furthermore, they have not committed any fumbles but have recorded 4 interceptions. The Hoosiers’ defense has been active for 370 plays, ranking 72nd in college football, while they allow only 11.8 points per game, putting them 5th in D-1.

Who will prevail in this college football showdown between the Buckeyes and Hoosiers?

Expert Recommendation: Bet on the Hoosiers +3.5

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Pick: Indiana Hoosiers +3.5
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