St. Louis Cardinals vs Cincinnati Reds Matchup Insights, 5/22/2026 MLB Picks, Best Bets & Odds

Home » St. Louis Cardinals vs Cincinnati Reds Matchup Insights, 5/22/2026 MLB Picks, Best Bets & Odds

  • Matchup: St. Louis Cardinals vs Cincinnati Reds
  • Date: Friday, May 22, 2026
  • Venue: Great American Ball Park in Cincinnati, OH
  • Broadcast: Reds.TV
  • Betting Odds: St. Louis (+132) Cincinnati (-160)

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The St. Louis Cardinals (28-20) are gearing up to visit Great American Ball Park on Friday, looking to secure a win against the Cincinnati Reds (26-24). The current betting line has the Cardinals at +132, while the Reds are favored at -160. The total runs are set at 8.5, with Kyle Leahy and Chris Paddack as the starting pitchers.

MLB Predictions by Victor Scott II for St. Louis Cardinals

This season, the Cardinals have recorded 71 doubles and hit 55 home runs as a team. With a slugging percentage of .389, they have struck out 388 times while drawing 164 walks. Averaging 4.5 runs per game places them 11th in the league. They’ve accumulated 210 RBIs along with 387 hits, boasting a team batting average of .240 and an on-base percentage of .321.

The Cardinals currently hold a team ERA of 4.21, ranking 18th in the league, and have struck out 349 batters. Their pitchers have allowed 50 home runs and a total of 218 runs, placing them 15th in the league. With 180 walks issued, the team’s FIP stands at 4.41. They’ve given up 422 hits (an average of 8.7 hits per 9 innings) and yielded 203 earned runs, showing a K/BB ratio of 1.94 and a WHIP of 1.39.

The Cardinals’ relief pitchers boast a save rate of 65.4%, participating in 71 save opportunities this season. They’ve secured 17 saves while blowing 9 out of 26 chances. The bullpen has inherited 75 base runners, with 34.7% scoring. They’ve entered 54 high-leverage situations, deploying 173 relief pitchers this season, achieving a league-leading 43 holds.

The St. Louis Cardinals have achieved 1,303 putouts, 468 assists, and recorded 23 errors this season. Their fielding percentage stands at .987, ranking 12th in MLB, with 50 double plays turned. They’ve managed to convert 69.5% of balls in play into outs across 3,909 innings on defense, sitting at 21st in professional baseball.

Leahy has pitched a total of 183 innings, accumulating 149 career strikeouts. Holding a career record of 10-7, his FIP is 3.68, having faced 774 major league hitters. With an earned run average of 3.73 (76 earned runs allowed) and a WHIP of 1.298, he has conceded 175 hits (8.6 hits per 9 innings) and issued 63 walks.

The Cincinnati Reds have amassed 63 home runs this season along with 208 RBIs. They’ve belted 78 doubles, walked 192 times, and scored 221 runs. Currently, their on-base percentage is .312, pairing with a batting average of .229. With a slugging percentage of .394, the Reds average 4.42 runs per game, placing them 14th in MLB. They’ve been struck out 453 times (6th in baseball) and recorded 384 hits.

The Reds have a WHIP of 1.458 while sporting a FIP of 5.05 as a pitching staff, ranking 22nd in MLB for total hits allowed (418). Their team ERA is 4.71 (surrendering 233 earned runs), and the K/BB ratio is at 7.90 (389 strikeouts against 231 walks). With 68 home runs allowed, they yield an average of 5.03 runs per 9 innings, placing them 25th in baseball.

Cincinnati’s relief pitchers have an inherited run scoring rate of 30.7%, from 75 inherited base runners. They’ve appeared in 62 high-leverage situations and have faced runners on base 54 times. With 60 save situations, they have notched 37 holds and encountered 9 blown saves. Ranked 20th in MLB, their save percentage sits at 59.1% while summoning 187 relief pitchers this season.

The Reds have turned 46 double plays, currently sporting a .988 fielding percentage (10th in professional baseball). Their season stats include 422 assists, 22 errors, and 1,336 putouts. Throughout 4,008 defensive innings, their efficiency stands at 70.9% (10th in the league).

Paddack has allowed 628 hits in his professional career while accumulating 559 strikeouts over 616 innings. With a career record of 32-41, his ERA stands at 4.79, allowing 9.2 hits per 9 innings. He has conceded a total of 328 earned runs, presenting a WHIP of 1.241 and a FIP of 4.7. His K/BB ratio is 4.08, having faced 2,610 opposing batters throughout his career.

Which team will triumph in tonight’s MLB clash, considering the spread or moneyline?

Prediction: Back Cincinnati (-160)

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Pick: Cincinnati Reds (-160)
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