Matchup: Milwaukee Brewers vs. San Diego Padres
Date: Tuesday, September 23, 2025
Venue: Petco Park, San Diego, CA
Broadcast: Padres.TV
Betting Odds: Milwaukee (-160) San Diego (+132)
The San Diego Padres (85-71) are set to host the Milwaukee Brewers (95-61) at Petco Park this Tuesday. The current betting line favors Milwaukee at -160, while San Diego is at +132, with a total set at 9 runs. Starting on the mound are Bruce Zimmermann for the Brewers and Randy Vasquez for the Padres.

As a collective unit, the Milwaukee Brewers are averaging 5.1 runs per game, placing them third in the league. They have achieved a total of 789 runs with an on-base percentage of .334. The team has hit 256 doubles and launched 163 home runs this season, totaling 733 RBIs and 1,378 hits, with a batting average of .261. Milwaukee’s slugging percentage stands at .409, with 1,203 strikeouts and 537 walks.
The Brewers have a strikeout-to-walk ratio of 2.72, accompanied by a WHIP of 1.23 from their pitching staff. They have allowed 159 home runs and 604 runs (3rd in the Majors). Their overall earned run average is 3.61 (2nd in MLB), with 1,374 strikeouts and 506 walks, while their FIP is currently 3.89.
In high-leverage situations, Brewers relievers have appeared 176 times, securing 101 holds this season (5th in MLB). Their save rate is 69.4% from 167 save opportunities, with 43 successful saves and 19 blown saves. This year, 208 runners have been inherited by the bullpen, and 30.8% of these have scored. The Brewers have utilized 523 relievers throughout the season.
Defensively, the Brewers have converted 70.7% of balls in play into outs over 12,417 innings, ranking them 8th in Major League Baseball. The Miami Marlins have recorded 4,139 putouts this season, along with 1,239 assists and 72 errors. Their fielding percentage stands at .987, placing them 11th in the league, with 117 double plays turned.
Zimmermann, with a career record of 8-10, has a FIP of 5.50 after facing 697 batters. He has allowed 195 hits (11.1 per 9 innings) and 36 walks, with an ERA of 5.58 (98 earned runs). His WHIP is at 1.461, having pitched 158 innings and recording 126 strikeouts so far in his career.
The San Diego Padres have a team slugging percentage of .388 and score an average of 4.27 runs per game (18th in MLB). They have logged 248 doubles, with 488 walks and 662 runs batted in. The Padres have hit 141 home runs this season while striking out 1,102 times (28th in the league) and accumulating 1,306 total hits. Their on-base percentage is .321, with a team batting average of .252 this year.
San Diego’s pitching staff has allowed 603 runs and holds a team ERA of 3.69 (561 earned runs). They have yielded 173 home runs and permit an average of 3.97 runs per 9 innings (3rd in MLB). The Padres have a WHIP of 1.202 and a FIP of 4.03 for the season. Their strikeout-to-walk ratio is an impressive 8.90 (1,356 strikeouts to 497 walks), and they lead the league in total hits allowed at 1,147.
The Padres have been in 167 save situations this year, achieving 99 holds and experiencing 16 blown saves. They have used their relief pitchers in 63 save chances, achieving 47 saves. In high-pressure scenarios, the Padres have turned to their bullpen 199 times and have had relief pitchers pitch with runners on base 175 times. Their inherited scoring percentage stands at 29.6%, and currently, they lead the league with a save rate of 74.6%, having utilized 547 relief pitchers this season.
Over 12,312 innings, the Padres boast a defensive efficiency rate of 71.8% (2nd in Major League Baseball). They have turned 109 double plays and have a fielding percentage of .987 (9th in MLB). This season, the Padres have recorded 1,168 assists, 70 errors, and 4,104 putouts.
In his career, Vasquez has allowed 270 hits and has notched 169 strikeouts in 260 innings pitched. Holding an 11-16 record, his earned run average is 4.15, with an average of 9.3 hits allowed per 9 innings. He has given up 120 earned runs, possessing a WHIP of 1.409 and a FIP of 4.1, with a K/BB ratio of 1.74 against 1,137 batters faced in his professional baseball tenure.
Who will emerge victorious in tonight’s MLB showdown against the spread or moneyline?
Recommendation: Back Milwaukee (-160)
