Tampa Bay Rays vs Baltimore Orioles Prediction for 9/23/2025 MLB Picks, Best Bets & Odds Overview

Home » Tampa Bay Rays vs Baltimore Orioles Prediction for 9/23/2025 MLB Picks, Best Bets & Odds Overview
  • Game: Tampa Bay Rays vs. Baltimore Orioles
  • Date: Tuesday, September 23, 2025
  • Location: Oriole Park at Camden Yards, Baltimore, MD
  • Broadcast: MASN
  • Betting Odds: Tampa Bay (-145) Baltimore (+125)

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The highly anticipated matchup at Oriole Park at Camden Yards features the Baltimore Orioles (73-83) facing off against the Tampa Bay Rays (76-80) this Tuesday. The betting odds favor the Rays at -145, while the Orioles are positioned at +125. The total runs set for this game is 8.5. Starting pitchers for the contest will be Ryan Pepiot and Dean Kremer.

mlb picks Colton Cowser Baltimore Orioles predictions best bet odds

The Tampa Bay Rays have been averaging 4.5 runs per game, placing them 15th in the league. Overall, they have amassed 689 runs this season, supported by a team on-base percentage of .314. The Rays have recorded 234 doubles and hit 176 home runs, accumulating 657 RBIs and 1,315 hits, with a batting average of .251. Their slugging percentage stands at .403, accompanied by 1,331 strikeouts and 448 walks.

The Rays’ pitching staff boasts a K/BB ratio of 3.02 and a team WHIP of 1.21. They have conceded 195 home runs and allowed 644 runs, ranking 10th in MLB. Their ERA stands at 3.85 for the season, making them 11th overall, and they have recorded 1,348 strikeouts. While allowing 1,214 hits (an average of 8.0 per 9 innings), the Rays’ pitchers have issued 447 walks, with an FIP of 4.15 this season.

Rays relievers have entered the game with runners on base 108 times while being involved in 152 high-leverage scenarios. The bullpen has achieved 85 holds this year (16th in MLB) and boasts a save percentage of 55.6%, having participated in 150 save situations and recording 35 saves despite failing to convert 28 of their 63 opportunities. This season, relievers have inherited 160 runners, with 31.3% scoring.

Defensively, the Rays have converted 70.7% of balls in play into outs across 12,360 innings, placing them 6th in professional baseball. They’ve totaled 4,120 putouts, 1,365 assists, and 78 errors for a fielding percentage of .986, landing them in 15th place and achieving 142 double plays.

Pepiot has pitched 372 innings in his career, striking out 386 batters. With a personal record of 24-20, he has a FIP of 3.45, faced 1,524 batters, and holds an earned run average (ERA) of 3.51 with 145 earned runs allowed, achieving a WHIP of 1.144 and yielding 286 hits (averaging 6.9 hits per nine innings), along with 140 walks.

The Baltimore Orioles reach a slugging percentage of .396 and average 4.23 runs per game (ranked 22nd in MLB). The team has logged 246 doubles, walked 455 times, and scored 655 runs this season, hitting 181 home runs. They’ve also been struck out 1,386 times (4th in the league) with 1,235 hits, marking a .306 on-base percentage and .238 batting average.

With a WHIP of 1.367, the Orioles have a combined FIP of 4.41. Their K/BB ratio registers at 8.40 (1,285 strikeouts against 502 walks), ranking them 26th for total hits allowed (1,373). The Orioles have given up 205 home runs, allowing 4.94 runs every 9 innings (24th in MLB), with a season ERA of 4.60 indicative of 701 earned runs conceded.

The Orioles’ bullpen has a 26.1% inherited score percentage for their 207 inherited runners. The relievers have entered 163 high-leverage situations and 149 instances with runners on base, accruing 105 holds among 167 save opportunities and 20 blown saves. Ranked 8th in MLB with a 65.5% save rate, they have used 518 relievers this season, achieving 38 saves.

In their 12,345 innings, the Orioles showcase a defensive efficiency of 68.5% (26th in the league). They have facilitated 117 double plays and maintain a fielding percentage of .985 (19th among major league teams). This season, the team recorded 1,361 assists, 83 errors, and 4,115 putouts.

Kremer has allowed 644 hits throughout his professional career, accumulating 572 strikeouts over 664 innings. His career record stands at 40-40, with an earned run average of 4.31 and allowing 8.7 hits per nine innings. Kremer has given up 318 earned runs, boasting a WHIP of 1.303 and a FIP of 4.2, exhibiting a strikeout-to-walk ratio of 2.59 against 2,809 batters faced.

Who will emerge victorious in this MLB showdown, covering the spread or moneyline?

Selection: Opt for Baltimore (+125)

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Pick: Baltimore Orioles (+125)
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