- Matchup: Arizona Diamondbacks vs. San Diego Padres
- Date: Friday, September 25, 2026
- Venue: Petco Park, San Diego, CA
- Broadcast: Padres.TV
- Odds/Point Spread: Arizona (+125) San Diego (-150)
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The Arizona Diamondbacks (83-74) are set to face off against the San Diego Padres (87-70) at Petco Park this Friday. In this exciting clash, Arizona comes in with a moneyline of +125, while San Diego is favored at -150. The over/under for this game is established at 8. Expect Brandon Pfaadt and Casey Mize as the starting pitchers.

The Diamondbacks have managed a total of 263 doubles and 158 home runs this season. With a slugging percentage of .399, they have been struck out 1,158 times while drawing 521 walks. Averaging 4.5 runs per game, Arizona ranks 15th in Major League Baseball. They have 669 RBIs and 1,289 hits, maintaining a batting average of .245 and scoring 700 runs with a team on-base percentage of .316.
The Diamondbacks showcase a team ERA of 4.09 this season, placing them 12th in MLB, while their pitchers have struck out a total of 1,105 hitters. They have given up 179 home runs and allowed 696 runs, ranking 14th in the league. With 468 walks and a FIP of 4.33, Arizona has yielded 1,310 base hits, averaging 8.4 per nine innings. Their K/BB ratio stands at 2.36, and they carry a collective WHIP of 1.27.
Arizona’s bullpen has a save rate of 67.3%, entering 137 save situations. This season, they’ve accumulated 37 saves while failing to convert 18 of 55 opportunities. The relievers have inherited 201 runners, with 26.9% scoring. Diamondbacks pitchers have stepped onto the mound with runners on base 139 times, comprising 167 high-leverage appearances. The team has used 529 relief pitchers this season, achieving 81 holds, which ranks 19th in baseball.
This season, the Diamondbacks have successfully converted 71.3% of balls in play into outs over 12,591 innings, positioning them 7th in the league. They boast 4,197 putouts, 1,355 assists, and 64 errors, maintaining a fielding percentage of .989, ranking 3rd in MLB. They’ve turned 135 double plays.
Brandon Pfaadt, with a career record of 34-31, has a FIP of 4.75 after facing 2,479 batters. He allowed 610 hits with a rate of 9.4 hits per nine innings, and issued 135 walks. His ERA stands at 4.82 (312 earned runs allowed) with a career WHIP of 1.280. Pfaadt has pitched 582 innings and accumulated 513 strikeouts.
The San Diego Padres hold a team on-base percentage of .318 and a batting average of .243 this season. They’ve struck out 1,267 times, ranking 23rd in the league, with 1,266 hits. The Padres have hit 179 home runs and recorded 665 RBIs, boasting a slugging percentage of .398 and averaging 4.39 runs per game (19th in MLB). Additionally, they have achieved 228 doubles and drawn 538 walks, scoring a total of 690 runs.
San Diego’s pitching unit has allowed 656 runs this season, with a team ERA of 3.96 (612 earned runs). They’ve given up 176 home runs and allowed 4.24 runs per nine innings, ranking 9th in baseball. With a team WHIP of 1.289 and a collective FIP of 4.19, their strikeout to walk ratio stands at 8.20 (1,275 strikeouts against 532 walks). The Padres rank 13th in total hits allowed with 1,261.
Relievers for San Diego have faced a 31.3% inherited score rate from 243 base runners. Their bullpen has 184 high-leverage situations as well as 150 appearances with runners on base. With 172 save opportunities, the Padres have recorded 102 holds and 19 blown saves. They hold the 8th position in the league with a 71.2% save rate and have utilized 531 bullpen pitchers throughout the season.
Defensively, the Padres have a efficiency rating of 70.7% over 12,522 innings (10th in professional baseball). They’ve executed 127 double plays and achieved a fielding percentage of .989 (2nd in the majors). This year, they have 1,387 assists, 63 errors, and 4,174 putouts.
Throughout his career, Casey Mize has allowed 495 hits while accumulating 389 strikeouts across 480 innings pitched. He permitted 235 earned runs with a WHIP of 1.318 and a FIP of 4.3. Mize’s strikeout to walk ratio is 2.82, and he has faced a total of 2,056 opposing batters. Holding a 25-28 career record, Mize has a 4.40 ERA, giving up an average of 9.3 hits per nine innings.
Which team will emerge victorious in tonight’s MLB showdown against the spread or moneyline?
Prediction: Bet on Arizona (+125)
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