- Matchup: Louisville Cardinals vs Syracuse Orange
- Date: Saturday, October 17, 2026
- Venue: JMA Wireless Dome, Syracuse, NY
- Broadcast: ACC Network
- Betting Odds: Orange (+14.0)
- Over/Under: 55.5
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The Syracuse Orange (2-3) are set to clash with the Louisville Cardinals (3-3) on Saturday, October 17, 2026, at the JMA Wireless Dome. According to betting odds, Syracuse is a 14-point underdog, and the total points have been established at 55.5.
This season, the Louisville Cardinals boast a 3-3 record. In their most recent outing, the Cardinals triumphed over the Florida State Seminoles with a commanding 44-20 victory. They executed 43 rushing attempts, accumulating 397 yards at an impressive average of 9.2 yards per carry. Overall, Louisville registered 58 plays, amassing 537 total yards. Defensively, they allowed 21 completions on 38 attempts for 209 yards, achieving a completion rate of 55.3%. Against the run, Louisville conceded 153 yards over 39 carries, averaging 3.9 yards per attempt.
This year, the Cardinals have racked up a total of 2,967 yards. They boast a balanced attack with 10 passing touchdowns and 21 rushing touchdowns, while turning the ball over 4 times. The team has achieved 138 first downs and incurred 43 penalties totaling 447 yards. On average, they rush for 231.7 yards, placing them 11th nationally. The Cardinals score an average of 39.5 points per game.
However, the Cardinals rank 104th nationwide in allowing points, giving up 27.7 per contest. Opponents average 3.9 yards per rush and 155.7 rushing yards per game. This season, Louisville has allowed 934 rushing yards over 6 games. In the air, they’ve surrendered 1,543 yards, ranking 127th overall, with an average of 257.2 passing yards allowed per game and a completion percentage of 60.3%. Their total defensive yardage averages 412.8 per game, placing them 123rd nationally. They’ve allowed 10 passing touchdowns and 9 rushing touchdowns this season.
The Syracuse Orange enter this match with a 2-3 record. Their last game resulted in a thrilling 42-41 victory against the Connecticut Huskies. In that game, Syracuse rushed for 3.6 yards per carry, totaling 174 yards on 48 attempts, and accumulating 509 yards across 85 plays (averaging 6.0 yards per play). Their pass defense held a completion percentage of 50.0%, allowing 318 yards on 20 completions from 40 attempts. They surrendered 34 rushing attempts for 181 yards at an average of 5.3 yards per carry.
In terms of offensive output, Syracuse ranks 52nd nationally, averaging 32.8 points per game. The Orange have an average of 447.4 yards per game, placing them 37th. Syracuse has drawn 478 penalty yards from 53 infractions, ranking 5th in Division 1. They’ve thrown 7 interceptions, lost no fumbles, and achieved 136 first downs. Throughout the season, they’ve amassed 1,408 passing yards and average 281.6 passing yards per game, making them 20th in the nation. They carry an average of 165.8 rushing yards per game, totaling 829 rushing yards this season.
Syracuse’s defense has allowed 722 rushing yards (approximately 144.4 yards per game) and 9 rushing touchdowns. They’ve also allowed 6 passing touchdowns and rank 20th in Division 1, giving up 167.0 passing yards per game. Overall, they’ve surrendered 120 points this season, generating 4 fumbles and 2 interceptions in defensive play. Their defense has been on the field for 309 plays, placing them 16th in Division 1. Currently, the Orange allow 24.0 points per game, ranking 75th in the nation.
Who will emerge victorious in tonight’s battle between the Cardinals and the Orange against the spread?
Prediction: Choose the Cardinals -14.0
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