- Matchup: San Diego Padres vs. St. Louis Cardinals
- Date: Wednesday, June 17, 2026
- Venue: Busch Stadium, St. Louis, MO
- Broadcast: Cardinals.TV
- Betting Odds: San Diego (-160) St. Louis (+132)
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This Wednesday, the St. Louis Cardinals (39-31) will face off against the San Diego Padres (37-34) at Busch Stadium. The current moneyline reflects San Diego at -160 and St. Louis at +132, with the total runs set at 8.5. The game features starters Griffin Canning and Kyle Leahy on the mound.

The San Diego Padres have a slugging percentage of .361 and have recorded 597 strikeouts while earning 228 walks. They’ve driven in 265 runs and tallied 501 hits this season, boasting a batting average of .217. With a total of 98 doubles and 73 home runs, the Padres are averaging 3.8 runs per game, ranking them 30th in the league.
San Diego’s K/BB ratio is at 2.39, and as a collective, their pitching staff has a WHIP of 1.29. The Padres’ pitchers have given up 71 home runs this season, contributing to a total of 285 runs allowed (7th in MLB). They have conceded 564 hits (8.1 per 9 innings) and 273 earned runs, resulting in an ERA of 3.90 (8th in MLB). The staff has recorded 594 strikeouts while issuing 249 walks, holding a team FIP of 4.00.
The Padres’ relief pitching unit boasts a save rate of 71.0%, having participated in 77 save situations this year. They’ve successfully completed 22 saves and have failed in 9 of their 31 opportunities. This season, Padres’ relievers have inherited 123 base runners, with 30.1% scoring. They’ve entered games with runners on base 71 times, appearing in 80 high-leverage situations. This season, 239 different relievers have taken the mound, securing 44 holds (10th in MLB).
Defensively, the Padres have converted 70.4% of balls in play into outs across 5,670 innings, ranking 11th in the league. They have tallied 1,890 putouts, 636 assists, and 21 errors, holding a fielding percentage of .992, the best in MLB, while completing 63 double plays.
Starting pitcher Canning has a career win-loss record of 32-42, with a FIP of 4.74 over 2,665 batters faced. He has given up 601 hits (8.7 hits per 9 innings) and has issued 240 walks. His career ERA stands at 4.81 (332 earned runs allowed) and his WHIP is 1.354, collecting 592 strikeouts across 621 innings of MLB play.
The St. Louis Cardinals have recorded 83 home runs and driven in 311 runs this season. They’ve achieved 101 doubles, with 233 walks and a total of 322 runs scored. The team currently boasts an OBP of .323 and a batting average of .246. Their slugging percentage sits at .399, with an average of 4.60 runs per game (11th in MLB). They have struck out 564 times (23rd in MLB) while achieving 581 hits.
On the pitching front, the Cardinals have allowed 307 runs this season, with a team ERA of 4.09 (conceding 285 earned runs). They have given up 77 home runs and permit 4.41 runs per 9 innings (13th in MLB). The Cardinals possess a WHIP of 1.330 and a FIP of 4.26, with a strikeout-to-walk ratio of 7.80 (541 strikeouts versus 235 free passes). They rank 20th in overall hits allowed with 599.
The Cardinals are ranked 17th in MLB for save percentage at 62.9%, with 238 relief pitchers used this season. They have entered 85 high-leverage situations and faced base runners on 76 occasions. St. Louis has had 87 save opportunities, managing to secure 50 holds and have recorded 13 blown saves. Their relief pitchers have faced 35 save chances, converting 22 saves this season, with an inherited runner score percentage of 33.9% out of 112 inherited base runners.
In their 5,649 innings played, the Cardinals have achieved a defensive efficiency of 69.7% (18th in MLB). The team has executed 68 double plays and maintains a fielding percentage of .988 (10th in professional baseball), with 650 assists, 32 errors, and 1,883 putouts this season.
Leahy, in his MLB career, has surrendered 201 hits while achieving 167 strikeouts over 202 innings pitched. He has given up 89 earned runs, holding a WHIP of 1.331 and a FIP of 3.9. His K/BB ratio stands at 2.46, having faced 860 batters during his career. With a record of 10-7, Leahy has an ERA of 3.96, allowing 9.0 hits per nine innings.
Who do you think will dominate tonight’s MLB matchup against the spread or moneyline?
Prediction: Back San Diego (-160)
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