San Francisco Giants vs Arizona Diamondbacks Preview, 9/16/2025 MLB Predictions, Top Picks & Odds

Home » San Francisco Giants vs Arizona Diamondbacks Preview, 9/16/2025 MLB Predictions, Top Picks & Odds

Matchup: San Francisco Giants vs. Arizona Diamondbacks

Date: Tuesday, September 16, 2025

Venue: Chase Field, Phoenix, AZ

Broadcast: DBACKS.TV

Betting Odds: San Francisco Giants (-128), Arizona Diamondbacks (+106)

The San Francisco Giants (75-74) are set to face the Arizona Diamondbacks (75-75) at Chase Field this Tuesday. The moneyline for this game lists the Giants at -128 and the Diamondbacks at +106, with an over/under set at 8.5. The starting pitchers expected for this matchup are Carson Seymour and Eduardo Rodriguez.

MLB Predictions for Ketel Marte and Arizona Diamondbacks

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The Giants have a slugging percentage of .390, with a total of 1,265 strikeouts and 506 walks this season. They’ve scored 621 RBIs and recorded 1,177 hits, giving them a batting average of .238. San Francisco has contributed 222 doubles and launched 160 home runs, achieving a total of 651 runs and a team OBP of .313. Averaging 4.4 runs per game, the Giants rank 16th in the MLB.

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The Giants have a K/BB ratio of 2.67 and a WHIP of 1.30. Their pitchers have surrendered 127 home runs and 629 total runs (ranked 11th in the league). San Francisco has given up 1,250 hits (8.5 per 9 innings) along with 563 earned runs. This season, their collective ERA is 3.84, placing them 8th in MLB, with 1,256 strikeouts. They’ve issued 470 walks, and their FIP stands at 3.70 this year.

The bullpen has utilized 473 relievers so far in 2025, inheriting 178 runners, with 37.1% of those scoring. They’ve racked up 36 saves out of 55 opportunities, yielding a save percentage of 65.5%. In total, their bullpen has 79 holds, ranking 19th in the league. Giants relievers have entered 134 save situations with 111 outings featuring runners on base.

With a defensive efficiency of 68.2%, the Giants rank 28th. The team has recorded 3,959 putouts, 1,391 assists, and 86 errors, leading to a fielding percentage of .984, sitting at 22nd in professional baseball, and they’ve turned 123 double plays.

Seymour (1-3 win-loss record) has a FIP of 5.26, having faced 143 batters so far. In his career, he has allowed 37 hits (10.4 hits per nine innings) and issued 12 walks, posting an ERA of 5.34 with 19 earned runs. With a career WHIP of 1.531, Seymour has pitched 32 innings and struck out 22 batters to date.

The Arizona Diamondbacks have collected 203 home runs, with 723 RBIs this season. They’ve achieved 253 doubles, drawn 501 walks, and scored 743 runs. The Diamondbacks currently hold an OBP of .323 and a batting average of .250. Their slugging percentage stands at .434, with an impressive average of 4.95 runs per game (5th in MLB). They have registered 1,221 strikeouts (18th in the league) and 1,271 hits.

As a pitching staff, the Diamondbacks have a WHIP of 1.322 and a FIP of 4.29. They rank 24th for total hits allowed, giving up 1,300 this year. Their pitchers have conceded 720 runs with an ERA of 4.47, yielding 663 earned runs. The strikeout-to-walk ratio is 8.00 (1,185 strikeouts against 465 walks). They’ve permitted 179 home runs, allowing 4.85 runs per 9 innings (23rd in the league).

This season, Arizona’s bullpen has entered 70 save situations, achieving 41 saves. They rank 22nd with a save percentage of 58.6%, having deployed 461 relievers. Their bullpen has faced 154 high-leverage situations and 137 innings with inherited runners. With an inherited score percentage of 33.3% from 183 runners, they have achieved 86 holds and experienced 29 blown saves across 161 save chances.

In their 12,015 innings played, Arizona’s defense has an efficiency of 69.4% (20th in the league). The Diamondbacks have produced 120 double plays, showcasing a fielding percentage of .986 (15th in the majors). Their season stats include 1,355 assists, 76 errors, and 4,005 putouts.

In his MLB journey, Rodriguez has allowed 1,260 hits and recorded 1,284 strikeouts across 1,287 innings pitched. With a win-loss record of 93-65, he maintains a 4.17 ERA, yielding 8.8 hits per 9 innings. He has surrendered 597 earned runs, working with a WHIP of 1.328, and owns a FIP of 4.1. His K/BB ratio stands at 2.85, after facing 5,504 batters during his career.

Who will triumph in tonight’s MLB battle, covering the spread or clinching the moneyline?

Pick from Parlay’s Pundit: Back Arizona (+106) and the under on 8.5 runs

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