Cleveland Guardians vs Minnesota Twins Forecast, 9/21/2025 MLB Picks, Top Bets & Odds

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• Matchup: Cleveland Guardians vs Minnesota Twins
• Scheduled Date: Sunday, September 21, 2025
• Venue: Target Field, Minneapolis, MN
• Broadcast: Twins.TV
• Betting Odds: Cleveland (-128) Minnesota (+106)

The Minnesota Twins (66-86) are set to face off against the Cleveland Guardians (81-71) at Target Field this Sunday. Current odds place Cleveland at -128, while Minnesota opens at +106. The total runs over/under has been established at 8.5. The starting pitchers for this matchup will be Parker Messick and Joe Ryan.

This season, the Guardians have recorded a total of 223 doubles and launched 157 home runs. Cleveland showcases a slugging percentage of .372, with 1,259 strikeouts and 464 walks. Averaging 3.9 runs per game ranks them 27th in MLB. They’ve amassed 574 RBIs and 1,125 hits, with a season batting average of .226. The team has scored a total of 594 runs and holds an on-base percentage of .297.

The Guardians’ strikeout-to-walk ratio stands at 2.50, and their pitching staff possesses a collective WHIP of 1.28. Guardians pitchers have allowed 160 home runs and a total of 617 runs (6th in MLB). They’ve given up 1,224 hits (8.1 per 9 innings) and 563 earned runs, leading to a team ERA of 3.75 (5th in MLB). Their staff has recorded 1,268 strikeouts, issued 508 walks, and maintains a FIP of 4.05 this season.

Guardians relief pitchers have faced opponents on base 141 times, with 182 high-leverage appearances. The bullpen has achieved 108 holds, securing the 2nd spot in MLB. Cleveland’s bullpen demonstrates a 69.7% save percentage, converting 46 of their 66 save opportunities. They’ve allowed 32.6% of inherited runners to score this season, with a total of 500 relievers utilized in 2025.

Defensively, the Guardians convert 69.8% of balls in play into outs across 12,087 innings, ranking 17th in professional baseball. They have recorded 4,029 putouts, 1,252 assists, and 93 errors this season, culminating in a fielding percentage of .983, which places them 27th in the majors. They have successfully turned 114 double plays.

Parker Messick has pitched for 29 innings, striking out 22 batters in his MLB tenure. Undefeated with a 3-0 record, Messick’s FIP is 1.83, having faced 120 batters in the majors. He maintains an ERA of 1.86 (6 earned runs) and a WHIP of 1.340, giving up 35 hits (10.8 hits per nine innings) and issuing 4 walks.

The Minnesota Twins possess a team on-base percentage of .314, with a batting average of .240 for the season. They’ve struck out 1,262 times (16th in the league) and achieved 1,228 base hits. Throughout the season, Minnesota has recorded 182 home runs and 619 RBIs, with a team slugging percentage of .400, and averages 4.30 runs per game (18th in MLB). They have hit 234 doubles, drawn 473 walks, and accumulated 653 runs.

The Twins feature a team WHIP of 1.336 and a FIP of 4.16 this year. Their K/BB ratio stands at 8.60 (1,278 strikeouts to 437 walks), placing them 26th in MLB for total hits allowed with 1,350. They’ve surrendered 184 home runs and currently allow 4.98 runs per 9 innings, ranking 25th in the league. Minnesota’s pitching staff has given up 741 runs this season, with an ERA of 4.65 (692 earned runs allowed).

Relievers for Minnesota have an inherited score percentage of 35.4% out of 164 inherited base runners. They have entered high-leverage situations 165 times, and made 114 appearances with runners on base. With 143 save situations, the Twins have achieved 90 holds but also faced 24 blown saves. Currently, they rank 28th in the league with a save percentage of 52.9%, deploying 515 relievers this season, securing 27 saves out of 51 save opportunities.

Over 12,042 innings of play, the Twins hold a defensive efficiency of 68.1% (29th in MLB). They’ve executed 92 double plays and maintain a fielding percentage of .985 (18th in professional baseball). This season, Minnesota has tallied 1,146 assists, made 78 errors, and recorded 4,014 putouts.

In his professional career, Joe Ryan has allowed 524 hits while recording 705 strikeouts over 631 innings. Holding a career record of 46-34, Ryan has an earned run average of 3.78 and permits 7.5 hits per 9 innings. He has surrendered 265 earned runs, with a WHIP of 1.060 and a FIP of 3.7. His K/BB ratio stands at 4.86, having faced 2,560 batters during his career.

Who do you predict will emerge victorious in tonight’s MLB game against the spread or moneyline?

Prediction: Bet on Minnesota (+106)