San Francisco Giants vs Los Angeles Dodgers Predictions, 9/21/2025 MLB Picks, Top Bets & Odds

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• Matchup: San Francisco Giants vs Los Angeles Dodgers
• Date: Sunday, September 21, 2025
• Venue: Dodger Stadium, Los Angeles, CA
• Broadcasting on: Spectrum SportsNet LA
• Betting Odds: San Francisco (+162) Los Angeles (-196)

The Los Angeles Dodgers (86-67) are set to host the San Francisco Giants (76-77) at Dodger Stadium this Sunday. The current betting odds show San Francisco at +162, whereas Los Angeles is favored at -196. The total runs projected for the game are set at 9. Anticipated starting pitchers include Kai-Wei Teng and Tyler Glasnow.

The Giants have achieved a total of 225 doubles and smashed 162 home runs as a team. With a slugging percentage of .385, they’ve struck out 1,303 times and earned 521 walks. Averaging 4.3 runs per game places the San Francisco Giants 17th in the MLB rankings. They have accumulated 633 RBIs and 1,193 hits, while maintaining a batting average of .235 and a team on-base percentage (OBP) of .311, tallying 663 runs this season.

This season, the Giants possess a collective ERA of 3.83, ranking 9th in the league, and have struck out 1,275 hitters. They have allowed 129 home runs and a total of 646 runs (12th in MLB). The pitching staff has walked 483 hitters, maintaining a FIP of 3.72. With 1,281 hits allowed (averaging 8.5 hits per 9 innings) and 576 earned runs, they showcase a K/BB ratio of 2.64 and a WHIP of 1.30 for the year.

The Giants’ bullpen boasts a save rate of 65.5%, managing 134 save opportunities. They have faced 181 inherited baserunners this year, with 37.6% scoring. Pitchers have entered with opponents on base 115 times along with 162 appearances in clutch situations. With 485 relievers utilized this season, they have secured 79 holds (20th in MLB) and achieved 36 saves, failing to convert 19 out of 55 chances.

Teng has pitched 37 innings with 40 strikeouts throughout his MLB career. Holding a 2-4 win-loss record, he has a FIP of 7.39 and has faced 179 hitters. His earned run average stands at 7.50 (31 earned runs) with a WHIP of 1.774, allowing 43 hits (10.4 per nine innings) and issuing 23 walks.

The Los Angeles Dodgers have an OBP of .329 and a batting average of .254 this season. They have struck out 1,272 times (15th in MLB), achieving 1,313 hits. With 225 home runs and 747 RBIs, they are slugging at .439 while averaging 5.10 runs per game (3rd in MLB). Additionally, they have 244 doubles and 780 total runs, with 557 walks to their credit.

Los Angeles’s pitching staff has allowed 657 runs this season, maintaining a team ERA of 4.03 (608 earned runs). They have given up 171 home runs and allow 4.35 runs per 9 innings (15th in MLB). The Dodgers’ WHIP stands at 1.265 with a FIP of 4.04. Their strikeout-to-walk ratio is notable at 9.30 (1,397 strikeouts to 533 walks), ranking 5th for total hits allowed at 1,185.

The Dodgers’ bullpen pitchers hold a 26.1% inherited score rate from 218 inherited runners. They’ve participated in 169 high-leverage situations and combined for 183 save opportunities, achieving 114 holds with 24 failed saves. Their save rate of 62.5% places them 17th in baseball, deploying 543 relief pitchers throughout the season. Los Angeles has converted 40 saves out of 64 opportunities.

The Dodgers have executed 97 double plays and have a fielding rate of .988 (6th in baseball). This season, they’ve recorded 1,272 assists, 64 errors, and 4,048 putouts. The Dodgers’ defensive efficiency stands at 70.4%, ranking 10th in the MLB after 12,144 innings played.

In his MLB career, Glasnow has surrendered 566 hits and achieved 942 strikeouts over 745 innings. With 309 earned runs, he possesses a WHIP of 1.142 and a FIP of 3.7. His K/BB ratio stands at 3.31, facing 3,048 batters throughout his MLB tenure. Glasnow’s career win-loss record is 42-36, holding an ERA of 3.73 with 6.8 hits allowed per 9 innings.

Who will come out on top in tonight’s MLB matchup—will it be against the spread or moneyline?

Recommendation: Back Los Angeles (-196) and the under on 9 runs